Seroatlas · Human Serome Atlas

YY1

Transcriptional repressor protein YY1

Also known as: DELTA, INO80S, NF-E1, TYY1_HUMAN, UCRBP, YIN-YANG-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25490
Gene: YY1
Ensembl: ENSG00000100811
Chromosome: 14
Canonical length: 414 aa
Protein class: Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies

OverviewNCBI Gene

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>P25490|YY1
     1  MASGDTLYIA TDGSEMPAEI VELHEIEVET IPVETIETTV VGEEEEEDDD DEDGGGGDHG
    61  GGGGHGHAGH HHHHHHHHHH PPMIALQPLV TDDPTQVHHH QEVILVQTRE EVVGGDDSDG
   121  LRAEDGFEDQ ILIPVPAPAG GDDDYIEQTL VTVAAAGKSG GGGSSSSGGG RVKKGGGKKS
   181  GKKSYLSGGA GAAGGGGADP GNKKWEQKQV QIKTLEGEFS VTMWSSDEKK DIDHETVVEE
   241  QIIGENSPPD YSEYMTGKKL PPGGIPGIDL SDPKQLAEFA RMKPRKIKED DAPRTIACPH
   301  KGCTKMFRDN SAMRKHLHTH GPRVHVCAEC GKAFVESSKL KRHQLVHTGE KPFQCTFEGC
   361  GKRFSLDFNL RTHVRIHTGD RPYVCPFDGC NKKFAQSTNL KSHILTHAKA KNNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 62 nTPM
thymus: 59 nTPM
liver: 55 nTPM
tonsil: 45 nTPM
thyroid gland: 42 nTPM
placenta: 41 nTPM

Single-cell type

basal keratinocytes: 259 nCPM
neutrophils: 245 nCPM
esophageal apical cells: 239 nCPM
erythrocyte progenitors: 237 nCPM
suprabasal keratinocytes: 234 nCPM
syncytiotrophoblasts: 225 nCPM

Immune cell

eosinophil: 12 nTPM
neutrophil: 11 nTPM
NK-cell: 9.6 nTPM
naive B-cell: 8.3 nTPM
T-reg: 8.3 nTPM
memory CD8 T-cell: 5.9 nTPM

Brain region

cerebellum: 54 nTPM
white matter: 50 nTPM
cerebral cortex: 47 nTPM
hippocampal formation: 44 nTPM
thalamus: 42 nTPM
basal ganglia: 41 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YY1.

Disease | AllUniProt

Conditions YY1 is implicated in, by any mechanism.

Gabriele-de Vries syndrome (GADEVS) MIM:617557

Disease | GeneticClinVar

47 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Gabriele de Vries syndrome
Inborn genetic diseases
Intellectual disability
Neurodevelopmental disorder
Developmental and epileptic encephalopathy, 78

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 0.99
gnomAD missense Z: 3.31
DepMap mean gene effect: -0.76
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YY1 as an antibody target. Whether an autoantibody or antibody against YY1 could matter depends on whether native YY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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