Seroatlas · Human Serome Atlas

INO80E

INO80 complex subunit E

Also known as: CCDC95, FLJ90652, IN80E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBZ0
Gene: INO80E
Ensembl: ENSG00000169592
Chromosome: 16
Canonical length: 244 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim

OverviewNCBI Gene

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in nucleolus and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q8NBZ0|INO80E
     1  MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK SFLLDRLLQY
    61  ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP LGGAPSPSSL SLPPSTGFPL
   121  QASGVPSPYL SSLASSRYPP FPSDYLALQL PEPSPLRPKR EKRPRLPRKL KMAVGPPDCP
   181  VGGPLTFPGR GSGAGVGTTL TPLPPPKMPP PTILSTVPRQ MFSDAGSGDD ALDGDDDLVI
   241  DIPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INO80E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

testis: 49 nTPM
kidney: 48 nTPM
spinal cord: 46 nTPM
amygdala: 45 nTPM
hippocampal formation: 45 nTPM
blood vessel: 44 nTPM

Single-cell type

tuft cells: 81 nCPM
extravillous trophoblasts: 52 nCPM
early primary spermatocytes: 51 nCPM
enterocytes: 47 nCPM
choroid plexus epithelial cells: 46 nCPM
cytotrophoblasts: 44 nCPM

Immune cell

total PBMC: 22 nTPM
non-classical monocyte: 6.8 nTPM
classical monocyte: 6.1 nTPM
T-reg: 5.2 nTPM
eosinophil: 5.1 nTPM
plasmacytoid DC: 5.1 nTPM

Brain region

white matter: 42 nTPM
medulla oblongata: 40 nTPM
midbrain: 38 nTPM
cerebellum: 37 nTPM
basal ganglia: 37 nTPM
thalamus: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.01
gnomAD missense Z: -0.25
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

INO80 complex subunit E
INO80 complex subunit E, N-terminal
INO80 complex subunit E

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INO80E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INO80E as an antibody target. Whether an autoantibody or antibody against INO80E could matter depends on whether native INO80E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INO80E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INO80E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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