Seroatlas · Human Serome Atlas

HAUS7

HAUS augmin-like complex subunit 7

Also known as: HAUS7_HUMAN, UCHL5IP, UIP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99871
Gene
HAUS7
Ensembl
ENSG00000213397
Chromosome
X
Canonical length
358 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Plasma membrane,Centrosome,Basal body,Mid piece,Principal piece

OverviewNCBI Gene

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>Q99871|HAUS7
     1  MAGQDAGCGR GGDDYSEDEG DSSVSRAAVE VFGKLKDLNC PFLEGLYITE PKTIQELLCS
    61  PSEYRLEILE WMCTRVWPSL QDRFSSLKGV PTEVKIQEMT KLGHELMLCA PDDQELLKGC
   121  ACAQKQLHFM DQLLDTIRSL TIGCSSCSSL MEHFEDTREK NEALLGELFS SPHLQMLLNP
   181  ECDPWPLDMQ PLLNKQSDDW QWASASAKSE EEEKLAELAR QLQESAAKLH ALRTEYFAQH
   241  EQGAAAGAAD ISTLDQKLRL VTSDFHQLIL AFLQVYDDEL GECCQRPGPD LHPCGPIIQA
   301  THQNLTSYSQ LLQVVMAVAD TSAKAVETVK KQQGEQICWG GSSSVMSLAT KMNELMEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 100 nTPM
  • cervix: 45 nTPM
  • cerebral cortex: 41 nTPM
  • skin: 41 nTPM
  • hippocampal formation: 36 nTPM
  • basal ganglia: 29 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 38 nCPM
  • astrocytes: 23 nCPM
  • brain excitatory neurons: 10 nCPM
  • microglia: 8.4 nCPM
  • hepatic stellate cells: 6.5 nCPM
  • brain inhibitory neurons: 6.2 nCPM

Immune cell

  • intermediate monocyte: 70 nTPM
  • non-classical monocyte: 65 nTPM
  • classical monocyte: 56 nTPM
  • myeloid DC: 49 nTPM
  • memory B-cell: 46 nTPM
  • NK-cell: 41 nTPM

Brain region

  • cerebral cortex: 27 nTPM
  • hippocampal formation: 24 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 18 nTPM
  • amygdala: 17 nTPM
  • thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
0.38
DepMap mean gene effect
-1.2
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • HAUS augmin-like complex subunit 7-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS7 as an antibody target. Whether an autoantibody or antibody against HAUS7 could matter depends on whether native HAUS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HAUS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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