Seroatlas · Human Serome Atlas

NFRKB

Nuclear factor related to kappa-B-binding protein

Also known as: DKFZp547B2013, INO80G, NFRKB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P4R8
Gene: NFRKB
Ensembl: ENSG00000170322
Chromosome: 11
Canonical length: 1299 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protease binding activity. Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in Ino80 complex and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1299 residues, UniProt reviewed canonical sequence.

>Q6P4R8|NFRKB
     1  MDSLDHMLTD PLELGPCGDG HGTRIMEDCL LGGTRVSLPE DLLEDPEIFF DVVSLSTWQE
    61  VLSDSQREHL QQFLPQFPED SAEQQNELIL ALFSGENFRF GNPLHIAQKL FRDGHFNPEV
   121  VKYRQLCFKS QYKRYLNSQQ QYFHRLLKQI LASRSDLLEM ARRSGPALPF RQKRPSPSRT
   181  PEEREWRTQQ RYLKVLREVK EECGDTALSS DEEDLSSWLP SSPARSPSPA VPLRVVPTLS
   241  TTDMKTADKV ELGDSDLKIM LKKHHEKRKH QPDHPDLLTG DLTLNDIMTR VNAGRKGSLA
   301  ALYDLAVLKK KVKEKEEKKK KKIKTIKSEA EDLAEPLSST EGVAPLSQAP SPLAIPAIKE
   361  EPLEDLKPCL GINEISSSFF SLLLEILLLE SQASLPMLEE RVLDWQSSPA SSLNSWFSAA
   421  PNWAELVLPA LQYLAGESRA VPSSFSPFVE FKEKTQQWKL LGQSQDNEKE LAALFQLWLE
   481  TKDQAFCKQE NEDSSDATTP VPRVRTDYVV RPSTGEEKRV FQEQERYRYS QPHKAFTFRM
   541  HGFESVVGPV KGVFDKETSL NKAREHSLLR SDRPAYVTIL SLVRDAAARL PNGEGTRAEI
   601  CELLKDSQFL APDVTSTQVN TVVSGALDRL HYEKDPCVKY DIGRKLWIYL HRDRSEEEFE
   661  RIHQAQAAAA KARKALQQKP KPPSKVKSSS KESSIKVLSS GPSEQSQMSL SDSSMPPTPV
   721  TPVTPTTPAL PAIPISPPPV SAVNKSGPST VSEPAKSSSG VLLVSSPTMP HLGTMLSPAS
   781  SQTAPSSQAA ARVVSHSGSA GLSQVRVVAQ PSLPAVPQQS GGPAQTLPQM PAGPQIRVPA
   841  TATQTKVVPQ TVMATVPVKA QTTAATVQRP GPGQTGLTVT SLPATASPVS KPATSSPGTS
   901  APSASTAAVI QNVTGQNIIK QVAITGQLGV KPQTGNSIPL TATNFRIQGK DVLRLPPSSI
   961  TTDAKGQTVL RITPDMMATL AKSQVTTVKL TQDLFGTGGN TTGKGISATL HVTSNPVHAA
  1021  DSPAKASSAS APSSTPTGTT VVKVTPDLKP TEASSSAFRL MPALGVSVAD QKGKSTVASS
  1081  EAKPAATIRI VQGLGVMPPK AGQTITVATH AKQGASVASG SGTVHTSAVS LPSMNAAVSK
  1141  TVAVASGAAS TPISISTGAP TVRQVPVSTT VVSTSQAGKL PTRITVPLSV ISQPMKGKSV
  1201  VTAPIIKGNL GANLSGLGRN IILTTMPAGT KLIAGNKPVS FLTAQQLQQL QQQGQATQVR
  1261  IQTVPASHLQ QGTASGSSKA VSTVVVTTAP SPKQAPEQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NFRKB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 21 nTPM
skin: 20 nTPM
testis: 18 nTPM
epididymis: 16 nTPM
fallopian tube: 15 nTPM
thyroid gland: 15 nTPM

Single-cell type

differentiating spermatogonia: 86 nCPM
early primary spermatocytes: 63 nCPM
basal keratinocytes: 63 nCPM
suprabasal keratinocytes: 62 nCPM
undifferentiated spermatogonia: 62 nCPM
syncytiotrophoblasts: 47 nCPM

Immune cell

eosinophil: 5.9 nTPM
basophil: 5.8 nTPM
MAIT T-cell: 5.6 nTPM
memory CD4 T-cell: 5.4 nTPM
neutrophil: 5.2 nTPM
gdT-cell: 5.1 nTPM

Brain region

basal ganglia: 25 nTPM
cerebellum: 24 nTPM
choroid plexus: 24 nTPM
hippocampal formation: 21 nTPM
cerebral cortex: 20 nTPM
hypothalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.13
gnomAD missense Z: 1.53
DepMap mean gene effect: -0.38
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

DEUBAD domain
Nuclear factor related to kappa-B-binding protein
Nuclear factor related to kappa-B-binding protein, winged helix-like domain
NFRKB winged helix-like domain superfamily
Nuclear factor related to kappa-B-binding protein, second winged helix domain
NFRKB Winged Helix-like
NFRKB second winged helix domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NFRKB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NFRKB as an antibody target. Whether an autoantibody or antibody against NFRKB could matter depends on whether native NFRKB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NFRKB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NFRKB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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