Seroatlas · Human Serome Atlas

FBXL16

F-box/LRR-repeat protein 16

Also known as: C16orf22, Fbl16, FXL16_HUMAN, MGC33974

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N461
Gene: FBXL16
Ensembl: ENSG00000127585
Chromosome: 16
Canonical length: 479 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

479 residues, UniProt reviewed canonical sequence.

>Q8N461|FBXL16
     1  MSSPGIDGDP KPPCLPRNGL VKLPGQPNGL GAASITKGTP ATKNRPCQPP PPPTLPPPSL
    61  AAPLSRAALA GGPCTPAGGP ASALAPGHPA ERPPLATDEK ILNGLFWYFS ACEKCVLAQV
   121  CKAWRRVLYQ PKFWAGLTPV LHAKELYNVL PGGEKEFVNL QGFAARGFEG FCLVGVSDLD
   181  ICEFIDNYAL SKKGVKAMSL KRSTITDAGL EVMLEQMQGV VRLELSGCND FTEAGLWSSL
   241  SARITSLSVS DCINVADDAI AAISQLLPNL AELSLQAYHV TDTALAYFTA RQGHSTHTLR
   301  LLSCWEITNH GVVNVVHSLP NLTALSLSGC SKVTDDGVEL VAENLRKLRS LDLSWCPRIT
   361  DMALEYVACD LHRLEELVLD RCVRITDTGL SYLSTMSSLR SLYLRWCCQV QDFGLKHLLA
   421  LGSLRLLSLA GCPLLTTTGL SGLVQLQELE ELELTNCPGA TPELFKYFSQ HLPRCLVIE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 505 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 505 nTPM
cerebral cortex: 486 nTPM
amygdala: 372 nTPM
hippocampal formation: 352 nTPM
cerebellum: 130 nTPM
hypothalamus: 76 nTPM

Single-cell type

brain inhibitory neurons: 46 nCPM
brain excitatory neurons: 38 nCPM
retinal bipolar cells: 33 nCPM
esophageal apical cells: 28 nCPM
other brain neurons: 24 nCPM
retinal horizontal cells: 24 nCPM

Immune cell

naive CD4 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

basal ganglia: 1,058 nTPM
cerebral cortex: 862 nTPM
hippocampal formation: 794 nTPM
amygdala: 788 nTPM
white matter: 523 nTPM
thalamus: 374 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.97
gnomAD missense Z: 3.14
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL16 as an antibody target. Whether an autoantibody or antibody against FBXL16 could matter depends on whether native FBXL16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...