Seroatlas · Human Serome Atlas

FBXL20

F-box/LRR-repeat protein 20

Also known as: Fbl2, Fbl20, FXL20_HUMAN, MGC15482

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96IG2
Gene
FBXL20
Ensembl
ENSG00000108306
Chromosome
17
Canonical length
436 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q96IG2|FBXL20
     1  MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL
    61  DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE
   121  VLNLNGCTKT TDATCTSLSK FCSKLRHLDL ASCTSITNMS LKALSEGCPL LEQLNISWCD
   181  QVTKDGIQAL VRGCGGLKAL FLKGCTQLED EALKYIGAHC PELVTLNLQT CLQITDEGLI
   241  TICRGCHKLQ SLCASGCSNI TDAILNALGQ NCPRLRILEV ARCSQLTDVG FTTLARNCHE
   301  LEKMDLEECV QITDSTLIQL SIHCPRLQVL SLSHCELITD DGIRHLGNGA CAHDQLEVIE
   361  LDNCPLITDA SLEHLKSCHS LERIELYDCQ QITRAGIKRL RTHLPNIKVH AYFAPVTPPP
   421  SVGGSRQRFC RCCIIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • testis: 12 nTPM
  • bone marrow: 7.7 nTPM
  • retina: 7.7 nTPM
  • thymus: 7 nTPM
  • cerebellum: 6.3 nTPM
  • skin: 6.2 nTPM

Single-cell type

  • sertoli cells: 529 nCPM
  • neutrophils: 519 nCPM
  • retinal ganglion cells: 332 nCPM
  • myonuclei: 315 nCPM
  • cone photoreceptor cells: 263 nCPM
  • corticotrophs: 261 nCPM

Immune cell

  • basophil: 30 nTPM
  • neutrophil: 27 nTPM
  • eosinophil: 18 nTPM
  • T-reg: 8.4 nTPM
  • NK-cell: 8.2 nTPM
  • non-classical monocyte: 6.7 nTPM

Brain region

  • cerebral cortex: 60 nTPM
  • hypothalamus: 60 nTPM
  • cerebellum: 55 nTPM
  • basal ganglia: 55 nTPM
  • hippocampal formation: 54 nTPM
  • amygdala: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.26
gnomAD pLI
1
gnomAD missense Z
3.12
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL20 as an antibody target. Whether an autoantibody or antibody against FBXL20 could matter depends on whether native FBXL20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXL20. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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