FBXO39

Protein identityUniProt · HPA

UniProt accession

Q8N4B4

Gene

FBXO39

Ensembl

ENSG00000177294

Chromosome

17

Canonical length

442 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q8N4B4|FBXO39
     1  MDEESELIQP QDQSCWAFLP DLCLCRVFWW LGDRDRSRAA LVCRKWNQMM YSAELWRYRT
    61  ITFSGRPSRV HASEVESAVW YVKKFGRYLE HLEVKFMNPY NAVLTKKFQV TMRGLLSCLS
   121  KSNNRLKSLS IQYLELDRLV WRNSIRSSFI SSLSFFLKKM GKRLDYLNLK GARLTVEQGC
   181  QILDSLSYMR NENVISELNI EDYFSHHLAV YNSPQFKKTM STFHNLVSLN LNYNCISDEL
   241  LENLCENAST LRTINIKCHV HDPHGQVIWG MSWAKLARQA TNLKVNFFFE RIMKYERLAR
   301  ILLQEIPIRS ISLRSCYFSD PDCSMRPTLI DLLPTFRHTL QKLTCEFNNN HESLDEELHL
   361  LIISCRKLFY FKIWAFLDVS FVERILKSQK ERQCALRVFK ARIYTNRYET NEEDKTLQEI
   421  YRKYRKLIES ELSYFVIVYS VM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

29 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO39.

Disease | ImmuneIEDB

Conditions an epitope on FBXO39 was assayed in.

• colon adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

-0.06

DepMap mean gene effect

-0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

• SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• F-box domain
• Leucine-rich repeat domain superfamily
• F-box-like domain superfamily
• F-box only protein 31/39
• F-box-like

KeywordsUniProt

• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• SKP1