Seroatlas · Human Serome Atlas

CCNF

Cyclin-F

Also known as: CCNF_HUMAN, FBX1, FBXO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41002
Gene: CCNF
Ensembl: ENSG00000162063
Chromosome: 16
Canonical length: 786 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

786 residues, UniProt reviewed canonical sequence.

>P41002|CCNF
     1  MGSGGVVHCR CAKCFCYPTK RRIRRRPRNL TILSLPEDVL FHILKWLSVE DILAVRAVHS
    61  QLKDLVDNHA SVWACASFQE LWPSPGNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD
   121  EARAEVNGLK ASRFFSLAER LNVGAAPFIW LFIRPPWSVS GSCCKAVVHE SLRAECQLQR
   181  THKASILHCL GRVLSLFEDE EKQQQAHDLF EEAAHQGCLT SSYLLWESDR RTDVSDPGRC
   241  LHSFRKLRDY AAKGCWEAQL SLAKACANAN QLGLEVRASS EIVCQLFQAS QAVSKQQVFS
   301  VQKGLNDTMR YILIDWLVEV ATMKDFTSLC LHLTVECVDR YLRRRLVPRY RLQLLGIACM
   361  VICTRFISKE ILTIREAVWL TDNTYKYEDL VRMMGEIVSA LEGKIRVPTV VDYKEVLLTL
   421  VPVELRTQHL CSFLCELSLL HTSLSAYAPA RLAAAALLLA RLTHGQTQPW TTQLWDLTGF
   481  SYEDLIPCVL SLHKKCFHDD APKDYRQVSL TAVKQRFEDK RYGEISQEEV LSYSQLCAAL
   541  GVTQDSPDPP TFLSTGEIHA FLSSPSGRRT KRKRENSLQE DRGSFVTTPT AELSSQEETL
   601  LGSFLDWSLD CCSGYEGDQE SEGEKEGDVT APSGILDVTV VYLNPEQHCC QESSDEEACP
   661  EDKGPQDPQA LALDTQIPAT PGPKPLVRTS REPGKDVTTS GYSSVSTASP TSSVDGGLGA
   721  LPQPTSVLSL DSDSHTQPCH HQARKSCLQC RPPSPPESSV PQQQVKRINL CIHSEEEDMN
   781  LGLVRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

thymus: 14 nTPM
tonsil: 9 nTPM
bone marrow: 6.9 nTPM
lymph node: 6.9 nTPM
cerebellum: 4.6 nTPM
skin: 4.5 nTPM

Single-cell type

monocyte progenitors: 67 nCPM
erythrocyte progenitors: 45 nCPM
megakaryocyte progenitors: 30 nCPM
extravillous trophoblasts: 22 nCPM
retinal amacrine cells: 21 nCPM
neutrophil progenitors: 20 nCPM

Immune cell

NK-cell: 1.3 nTPM
memory CD8 T-cell: 0.9 nTPM
gdT-cell: 0.7 nTPM
memory B-cell: 0.6 nTPM
total PBMC: 0.6 nTPM
naive B-cell: 0.5 nTPM

Brain region

cerebellum: 8.6 nTPM
cerebral cortex: 8.1 nTPM
hypothalamus: 8 nTPM
basal ganglia: 7.6 nTPM
hippocampal formation: 7.6 nTPM
thalamus: 7.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCNF.

Disease | AllUniProt

Conditions CCNF is implicated in, by any mechanism.

Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 (FTDALS5) MIM:619141

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 224 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Frontotemporal dementia and/or amyotrophic lateral sclerosis 5

Disease | ImmuneIEDB

Conditions an epitope on CCNF was assayed in.

systemic scleroderma B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.13
gnomAD missense Z: 0.74
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNF as an antibody target. Whether an autoantibody or antibody against CCNF could matter depends on whether native CCNF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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