Seroatlas · Human Serome Atlas

FBXL19

F-box/LRR-repeat protein 19

Also known as: CXXC11, DKFZp434K0410, Fbl19, FXL19_HUMAN, JHDM1C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PCT2
Gene: FBXL19
Ensembl: ENSG00000099364
Chromosome: 16
Canonical length: 694 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q6PCT2|FBXL19
     1  MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK
    61  KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEEEKFGLS LMECTICNEI
   121  VHPGCLKMGK AEGVINAEIP NCWECPRCTQ EGRTSKDSGE GPGRRRADNG EEGASLGSGW
   181  KLTEEPPLPP PPPRRKGPLP AGPPPEDVPG PPKRKEREAG NEPPTPRKKV KGGRERHLKK
   241  VGGDACLLRG SDPGGPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPLA SAEGPAVPSP
   301  SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA RNGRRPARGS
   361  SGEKENRGGR RAVRPGSGGP LLSWPLGPAP PPRPPQLERH VVRPPPRSPE PDTLPLAAGS
   421  DHPLPRAAWL RVFQHLGPRE LCICMRVCRT WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV
   481  VRRQPRALDL SWTGVSKKQL MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR
   541  WIEDVKDSQL RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS
   601  ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR CPRLRRLDLR
   661  SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 35 nTPM
testis: 31 nTPM
hippocampal formation: 26 nTPM
amygdala: 25 nTPM
basal ganglia: 21 nTPM
cerebellum: 18 nTPM

Single-cell type

sertoli cells: 35 nCPM
pancreatic islet cells: 21 nCPM
retinal horizontal cells: 20 nCPM
proximal tubule cells: 18 nCPM
renal collecting duct intercalated cells: 18 nCPM
renal connecting tubule cells: 17 nCPM

Immune cell

NK-cell: 0.9 nTPM
plasmacytoid DC: 0.8 nTPM
eosinophil: 0.5 nTPM
memory B-cell: 0.5 nTPM
neutrophil: 0.5 nTPM
classical monocyte: 0.4 nTPM

Brain region

cerebral cortex: 83 nTPM
hippocampal formation: 61 nTPM
amygdala: 60 nTPM
white matter: 54 nTPM
basal ganglia: 52 nTPM
thalamus: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 3.87
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL19 as an antibody target. Whether an autoantibody or antibody against FBXL19 could matter depends on whether native FBXL19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...