Seroatlas · Human Serome Atlas

FBXW12

F-box/WD repeat-containing protein 12

Also known as: Fbw12, FBW12_HUMAN, FBXO35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6X9E4
Gene: FBXW12
Ensembl: ENSG00000164049
Chromosome: 3
Canonical length: 464 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q6X9E4|FBXW12
     1  MEIRLPDLAL KRIFSFLDLF GLLQVSQVNK HWNRIADSDY LWRSLSLQRW DCSNFTNQHL
    61  GTHTWKQFFL HQRRKELRLA LAQPHNFIYK VTKNIAFETE LAYLSGNRLT VDEQEKSIIC
   121  SVSPKQELCA WDVQEGTMIW SSPVQEFHFS NLVTLPQMHL AITMDRKKTI KVWNCQDRDA
   181  LAVLPMPQPC YCMEAYLTKD GPFLMVGDAA GDIYTFTLPG LRDVSKVTAF QYGIVLLHCS
   241  PDKKWVFACG TYSRTLPQVF LTESLLRPSE GSVPLSTFLP HKLCASACWT PKVKNRITLM
   301  SQSSTGKKTE FITFDLTTKK TGGQTVIQAY EIASFQVAAH LKCPIWMGAS DGYMIVFTSG
   361  PYLLLFSITG FLLQRFEDHQ AAINNFWVDP CYVLTTSENS VHVYMWEEGG RHPYLRSCCH
   421  LENTWHDHTT DSCISSVMCD NASIVLRVRK VSDSSILVMY SLNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXW12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 5.7 nTPM

Expression across tissuesHPA

Tissue

pancreas: 5.7 nTPM
testis: 0.7 nTPM
cerebellum: 0.5 nTPM
ovary: 0.4 nTPM
hippocampal formation: 0.3 nTPM
retina: 0.3 nTPM

Single-cell type

oocytes: 170 nCPM
epicardial cells: 50 nCPM
early spermatids: 19 nCPM
respiratory ionocytes: 15 nCPM
medullary thymic epithelial cells: 12 nCPM
müller glia: 9.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 1.7 nTPM
cerebral cortex: 1.6 nTPM
cerebellum: 1.3 nTPM
amygdala: 1.2 nTPM
basal ganglia: 1.2 nTPM
hypothalamus: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXW12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXW12 as an antibody target. Whether an autoantibody or antibody against FBXW12 could matter depends on whether native FBXW12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXW12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXW12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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