Seroatlas · Human Serome Atlas

FBXO15

F-box only protein 15

Also known as: FBX15, FBX15_HUMAN, MGC39671

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCQ5
Gene: FBXO15
Ensembl: ENSG00000141665
Chromosome: 18
Canonical length: 510 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q8NCQ5|FBXO15
     1  MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS AALRCHAGGG
    61  QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV SRRFYHLAND NFIWIGIYST
   121  AFSPARSNWK FNSVEKIAMS MSFLSVQDKE AGYWKKEYIT KQIASVKAAL ADILKPVNPY
   181  TGLPVKTKEA LRIFGLGWAI ILKEKGGKEY IMEHVDLSIN DTSVTVIWYG KKWPCLASLS
   241  TLDLCGMTPV FTDWYKTPTK HRLRWHSLIA KYNLSHLTIS TMIGCDRLIR IFCLHPGLLV
   301  GVWKKEEELA FVMANLHFHH LVERSTLGSA TIPYELPPHS PFLDDSPEYG LHGYQLHVDL
   361  HSGGVFYLCG TFRNLFTKRG NIENGHVKLI VIHLKNNREH LPLIGKVGLS WKTDIFDGCI
   421  KSCSMMDVTL LDEHGKPFWC FSSPVCLRSP ATPSDSSSFL GQTYNVDYVD AEGRVHVELV
   481  WIRETEEYLI VNLVLYLSIA KINHWFGTEY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 7.2 nTPM

Expression across tissuesHPA

Tissue

testis: 7.2 nTPM
fallopian tube: 3.8 nTPM
retina: 3.2 nTPM
choroid plexus: 2.8 nTPM
epididymis: 2.1 nTPM
basal ganglia: 1.5 nTPM

Single-cell type

ependymal cells: 233 nCPM
respiratory ciliated cells: 144 nCPM
fallopian tube ciliated cells: 85 nCPM
epididymal efferent duct ciliated cells: 82 nCPM
late primary spermatocytes: 71 nCPM
endometrial ciliated cells: 66 nCPM

Immune cell

naive CD4 T-cell: 1.6 nTPM
naive CD8 T-cell: 0.9 nTPM
memory CD4 T-cell: 0.5 nTPM
total PBMC: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

midbrain: 9.5 nTPM
medulla oblongata: 7.9 nTPM
white matter: 7.6 nTPM
spinal cord: 5.8 nTPM
pons: 5.7 nTPM
basal ganglia: 4.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.71
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO15 as an antibody target. Whether an autoantibody or antibody against FBXO15 could matter depends on whether native FBXO15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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