Seroatlas · Human Serome Atlas

FBXO40

F-box only protein 40

Also known as: Fbx40, FBX40_HUMAN, KIAA1195

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UH90
Gene: FBXO40
Ensembl: ENSG00000163833
Chromosome: 3
Canonical length: 709 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>Q9UH90|FBXO40
     1  MGKARRSPPG HHRHCEGCFN RHCHIPVEPN TSCLVISCHL LCGATFHMCK EAEHQLLCPL
    61  EQVPCLNSEY GCPLSMSRHK LAKHLQVCPA SVVCCSMEWN RWPNVDSETT LHENIMKETP
   121  SEECLDTALA LQDQKVLFRS LKMVELFPET REATEEEPTM NGETSVEEMG GAVGGVDIGL
   181  VPHGLSATNG EMAELSQEER EVLAKTKEGM DLVKFGQWEN IFSKEHAASA LTNSSASCES
   241  KNKNDSEKEQ ISSGHNMVEG EGAPKKKEPQ ENQKQQDVRT AMETTGLAPW QDGVLERLKT
   301  AVDAKDYNMY LVHNGRMLIH FGQMPACTPK ERDFVYGKLE AQEVKTVYTF KVPVSYCGKR
   361  ARLGDAMLSC KPSEHKAVDT SDLGITVEDL PKSDLIKTTL QCALERELKG HVISESRSID
   421  GLFMDFATQT YNFEPEQFSS GTVLADLTAA TPGGLHVELH SECVTRRHNK SSSAFTFTCN
   481  KFFRRDEFPL HFKNVHTDIQ SCLNGWFQHR CPLAYLGCTF VQNHFRPPGQ KAKVIYSQEL
   541  KTFAIKPEVA PELSEGRKNN HLLGHGGKSQ NSLTSLPLEI LKYIAGFLDS VSLAQLSQVS
   601  VLMRNICATL LQERGMVLLQ WKKKRYSHGG TSWRVHREIW QFSSLFSKIK SWEFNEVTSM
   661  SEHLKSCPFN IVEHKTDPIL LTSMCQPREQ ARESLVSTFR IRPRGRYVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 152 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 152 nTPM
tongue: 94 nTPM
heart muscle: 85 nTPM
esophagus: 1.1 nTPM
prostate: 0.9 nTPM
cerebral cortex: 0.8 nTPM

Single-cell type

myonuclei: 492 nCPM
cardiomyocytes: 428 nCPM
thymic myoid cells: 15 nCPM
epicardial cells: 11 nCPM
adipocytes: 8.9 nCPM
myosatellite cells: 3.5 nCPM

Immune cell

neutrophil: 0.5 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 3 nTPM
basal ganglia: 2.1 nTPM
white matter: 2.1 nTPM
pons: 1.6 nTPM
amygdala: 1.5 nTPM
hypothalamus: 1.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO40.

Disease | ImmuneIEDB

Conditions an epitope on FBXO40 was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

muscle cell differentiation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO40 as an antibody target. Whether an autoantibody or antibody against FBXO40 could matter depends on whether native FBXO40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...