Seroatlas · Human Serome Atlas

FBXO36

F-box only protein 36

Also known as: Fbx36, FBX36_HUMAN, FLJ37592

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEA4
Gene: FBXO36
Ensembl: ENSG00000153832
Chromosome: 2
Canonical length: 188 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO36, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q8NEA4|FBXO36
     1  MASWLPETLF ETVGQGPPPS KDYYQLLVTR SQVIFRWWKI SLRSEYRSTK PGEAKETHED
    61  FLENSHLQGQ TALIFGARIL DYVINLCKGK FDFLERLSDD LLLTIISYLD LEDIARLCQT
   121  SHRFAKLCMS DKLWEQIVQS TCDTITPDVR ALAEDTGWRQ LFFTNKLQLQ RQLRKRKQKY
   181  GNLREKQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 10 nTPM
retina: 8.3 nTPM
thyroid gland: 6.9 nTPM
testis: 5.6 nTPM
kidney: 4.7 nTPM
choroid plexus: 4.6 nTPM

Single-cell type

late primary spermatocytes: 177 nCPM
respiratory ciliated cells: 172 nCPM
ependymal cells: 118 nCPM
cone photoreceptor cells: 114 nCPM
fallopian tube ciliated cells: 105 nCPM
endometrial ciliated cells: 102 nCPM

Immune cell

naive CD4 T-cell: 1.4 nTPM
myeloid DC: 1.3 nTPM
T-reg: 1.2 nTPM
memory B-cell: 1.1 nTPM
NK-cell: 1 nTPM
gdT-cell: 0.8 nTPM

Brain region

medulla oblongata: 12 nTPM
midbrain: 11 nTPM
spinal cord: 10 nTPM
white matter: 9.4 nTPM
amygdala: 8.7 nTPM
thalamus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0
gnomAD missense Z: -0.4
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO36 as an antibody target. Whether an autoantibody or antibody against FBXO36 could matter depends on whether native FBXO36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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