Seroatlas · Human Serome Atlas

BCORL1

BCL-6 corepressor-like protein 1

Also known as: BCORL_HUMAN, CXorf10, FLJ11362

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5H9F3
Gene
BCORL1
Ensembl
ENSG00000085185
Chromosome
X
Canonical length
1785 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional corepressor that is found tethered to promoter regions by DNA-binding proteins. The encoded protein can interact with several different class II histone deacetylases to repress transcription. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

1785 residues, UniProt reviewed canonical sequence.

>Q5H9F3|BCORL1
     1  MISTAPLYSG VHNWTSSDRI RMCGINEERR APLSDEESTT GDCQHFGSQE FCVSSSFSKV
    61  ELTAVGSGSN ARGADPDGSA TEKLGHKSED KPDDPQPKMD YAGNVAEAEG LLVPLSSPGD
   121  GLKLPASDSA EASNSRADCS WTPLNTQMSK QVDCSPAGVK ALDSRQGVGE KNTFILATLG
   181  TGVPVEGTLP LVTTNFSPLP APICPPAPGS ASVPHSVPDA FQVPLSVPAP VPHSGLVPVQ
   241  VATSVPAPSP PLAPVPALAP APPSVPTLIS DSNPLSVSAS VLVPVPASAP PSGPVPLSAP
   301  APAPLSVPVS APPLALIQAP VPPSAPTLVL APVPTPVLAP MPASTPPAAP APPSVPMPTP
   361  TPSSGPPSTP TLIPAFAPTP VPAPTPAPIF TPAPTPMPAA TPAAIPTSAP IPASFSLSRV
   421  CFPAAQAPAM QKVPLSFQPG TVLTPSQPLV YIPPPSCGQP LSVATLPTTL GVSSTLTLPV
   481  LPSYLQDRCL PGVLASPELR SYPYAFSVAR PLTSDSKLVS LEVNRLPCTS PSGSTTTQPA
   541  PDGVPGPLAD TSLVTASAKV LPTPQPLLPA PSGSSAPPHP AKMPSGTEQQ TEGTSVTFSP
   601  LKSPPQLERE MASPPECSEM PLDLSSKSNR QKLPLPNQRK TPPMPVLTPV HTSSKALLST
   661  VLSRSQRTTQ AAGGNVTSCL GSTSSPFVIF PEIVRNGDPS TWVKNSTALI STIPGTYVGV
   721  ANPVPASLLL NKDPNLGLNR DPRHLPKQEP ISIIDQGEPK GTGATCGKKG SQAGAEGQPS
   781  TVKRYTPARI APGLPGCQTK ELSLWKPTGP ANIYPRCSVN GKPTSTQVLP VGWSPYHQAS
   841  LLSIGISSAG QLTPSQGAPI RPTSVVSEFS GVPSLSSSEA VHGLPEGQPR PGGSFVPEQD
   901  PVTKNKTCRI AAKPYEEQVN PVLLTLSPQT GTLALSVQPS GGDIRMNQGP EESESHLCSD
   961  STPKMEGPQG ACGLKLAGDT KPKNQVLATY MSHELVLATP QNLPKMPELP LLPHDSHPKE
  1021  LILDVVPSSR RGSSTERPQL GSQVDLGRVK MEKVDGDVVF NLATCFRADG LPVAPQRGQA
  1081  EVRAKAGQAR VKQESVGVFA CKNKWQPDDV TESLPPKKMK CGKEKDSEEQ QLQPQAKAVV
  1141  RSSHRPKCRK LPSDPQESTK KSPRGASDSG KEHNGVRGKH KHRKPTKPES QSPGKRADSH
  1201  EEGSLEKKAK SSFRDFIPVV LSTRTRSQSG SICSSFAGMA DSDMGSQEVF PTEEEEEVTP
  1261  TPAKRRKVRK TQRDTQYRSH HAQDKSLLSQ GRRHLWRARE MPWRTEAARQ MWDTNEEEEE
  1321  EEEEGLLKRK KRRRQKSRKY QTGEYLTEQE DEQRRKGRAD LKARKQKTSS SQSLEHRLRN
  1381  RNLLLPNKVQ GISDSPNGFL PNNLEEPACL ENSEKPSGKR KCKTKHMATV SEEAKGKGRW
  1441  SQQKTRSPKS PTPVKPTEPC TPSKSRSASS EEASESPTAR QIPPEARRLI VNKNAGETLL
  1501  QRAARLGYKD VVLYCLQKDS EDVNHRDNAG YTALHEACSR GWTDILNILL EHGANVNCSA
  1561  QDGTRPVHDA VVNDNLETIW LLLSYGADPT LATYSGQTAM KLASSDTMKR FLSDHLSDLQ
  1621  GRAEGDPGVS WDFYSSSVLE EKDGFACDLL HNPPGSSDQE GDDPMEEDDF MFELSDKPLL
  1681  PCYNLQVSVS RGPCNWFLFS DVLKRLKLSS RIFQARFPHF EITTMPKAEF YRQVASSQLL
  1741  TPAERPGGLD DRSPPGSSET VELVRYEPDL LRLLGSEVEF QSCNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCORL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.66
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 11 nTPM
  • testis: 6.1 nTPM
  • fallopian tube: 5.5 nTPM
  • parathyroid gland: 5.5 nTPM
  • bone marrow: 5.2 nTPM
  • endometrium: 5.2 nTPM

Single-cell type

  • syncytiotrophoblasts: 197 nCPM
  • oocytes: 152 nCPM
  • neutrophils: 65 nCPM
  • neutrophil progenitors: 54 nCPM
  • lactotrophs: 53 nCPM
  • tuft cells: 35 nCPM

Immune cell

  • neutrophil: 0.7 nTPM
  • eosinophil: 0.6 nTPM
  • classical monocyte: 0.3 nTPM
  • myeloid DC: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • cerebellum: 16 nTPM
  • medulla oblongata: 13 nTPM
  • cerebral cortex: 12 nTPM
  • hypothalamus: 12 nTPM
  • amygdala: 12 nTPM
  • midbrain: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCORL1.

Disease | AllUniProt

Conditions BCORL1 is implicated in, by any mechanism.

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 718 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
2.06
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCORL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCORL1 as an antibody target. Whether an autoantibody or antibody against BCORL1 could matter depends on whether native BCORL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCORL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCORL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BCORL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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