Seroatlas · Human Serome Atlas

FBXL14

F-box/LRR-repeat protein 14

Also known as: Fbl14, FXL14_HUMAN, MGC40195

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N1E6
Gene
FBXL14
Ensembl
ENSG00000171823
Chromosome
12
Canonical length
418 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q8N1E6|FBXL14
     1  METHISCLFP ELLAMIFGYL DVRDKGRAAQ VCTAWRDAAY HKSVWRGVEA KLHLRRANPS
    61  LFPSLQARGI RRVQILSLRR SLSYVIQGMA NIESLNLSGC YNLTDNGLGH AFVQEIGSLR
   121  ALNLSLCKQI TDSSLGRIAQ YLKGLEVLEL GGCSNITNTG LLLIAWGLQR LKSLNLRSCR
   181  HLSDVGIGHL AGMTRSAAEG CLGLEQLTLQ DCQKLTDLSL KHISRGLTGL RLLNLSFCGG
   241  ISDAGLLHLS HMGSLRSLNL RSCDNISDTG IMHLAMGSLR LSGLDVSFCD KVGDQSLAYI
   301  AQGLDGLKSL SLCSCHISDD GINRMVRQMH GLRTLNIGQC VRITDKGLEL IAEHLSQLTG
   361  IDLYGCTRIT KRGLERITQL PCLKVLNLGL WQMTDSEKEA RGDFSPLFTV RTRGSSRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • testis: 17 nTPM
  • pancreas: 11 nTPM
  • stomach: 9.1 nTPM
  • thymus: 7.7 nTPM
  • colon: 7.4 nTPM
  • cerebral cortex: 7.3 nTPM

Single-cell type

  • late spermatids: 130 nCPM
  • cone photoreceptor cells: 93 nCPM
  • pancreatic duct cells: 79 nCPM
  • pancreatic islet cells: 52 nCPM
  • monocytes: 52 nCPM
  • müller glia: 51 nCPM

Immune cell

  • naive B-cell: 1.7 nTPM
  • T-reg: 1.6 nTPM
  • basophil: 0.7 nTPM
  • NK-cell: 0.6 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 58 nTPM
  • basal ganglia: 34 nTPM
  • hippocampal formation: 34 nTPM
  • thalamus: 31 nTPM
  • cerebellum: 30 nTPM
  • white matter: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.83
gnomAD missense Z
2.95
DepMap mean gene effect
0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL14 as an antibody target. Whether an autoantibody or antibody against FBXL14 could matter depends on whether native FBXL14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXL14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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