Seroatlas · Human Serome Atlas

FBXO34

F-box only protein 34

Also known as: Fbx34, FBX34_HUMAN, FLJ20725

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWN3
Gene: FBXO34
Ensembl: ENSG00000178974
Chromosome: 14
Canonical length: 711 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>Q9NWN3|FBXO34
     1  MHLKPYWKLQ KKEHPPEVSR ETQRTPMNHQ KAVNDETCKA SHITSSVFPS ASLGKASSRK
    61  PFGILSPNVL CSMSGKSPVE SSLNVKTKKN APSATIHQGE EEGPLDIWAV VKPGNTKEKI
   121  AFFASHQCSN RIGSMKIKSS WDIDGRATKR RKKSGDLKKA KVQVERMREV NSRCYQPEPF
   181  ACGIEHCSVH YVSDSGDGVY AGRPLSVIQM VAFLEQRASA LLASCSKNCT NSPAIVRFSG
   241  QSRGVPAVSE SYSAPGACEE PTERGNLEVG EPQSEPVRVL DMVAKLESEC LKRQGQREPG
   301  SLSRNNSFRR NVGRVLLANS TQADEGKTKK GVLEAPDTQV NPVGSVSVDC GPSRADRCSP
   361  KEDQAWDGAS QDCPPLPAGV SFHIDSAELE PGSQTAVKNS NRYDVEMTDE LVGLPFSSHT
   421  YSQASELPTD AVDCMSRELV SLTSRNPDQR KESLCISITV SKVDKDQPSI LNSCEDPVPG
   481  MLFFLPPGQH LSDYSQLNES TTKESSEASQ LEDAAGGDSA SEEKSGSAEP FVLPASSVES
   541  TLPVLEASSW KKQVSHDFLE TRFKIQQLLE PQQYMAFLPH HIMVKIFRLL PTKSLVALKC
   601  TCCYFKFIIE YYNIRPADSR WVRDPRYRED PCKQCKKKYV KGDVSLCRWH PKPYCQALPY
   661  GPGYWMCCHR SQKGFPGCKL GLHDNHWVPA CHSFNRAIHK KAKGTEAEEE Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

tongue: 42 nTPM
esophagus: 32 nTPM
skeletal muscle: 29 nTPM
colon: 26 nTPM
rectum: 25 nTPM
testis: 23 nTPM

Single-cell type

neutrophils: 721 nCPM
esophageal apical cells: 699 nCPM
myonuclei: 588 nCPM
urothelial cells: 533 nCPM
neutrophil progenitors: 388 nCPM
late spermatids: 374 nCPM

Immune cell

non-classical monocyte: 14 nTPM
NK-cell: 13 nTPM
MAIT T-cell: 12 nTPM
classical monocyte: 11 nTPM
myeloid DC: 11 nTPM
memory CD8 T-cell: 11 nTPM

Brain region

cerebral cortex: 35 nTPM
hippocampal formation: 34 nTPM
basal ganglia: 26 nTPM
white matter: 19 nTPM
choroid plexus: 19 nTPM
thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.12
gnomAD missense Z: 0.49
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO34 as an antibody target. Whether an autoantibody or antibody against FBXO34 could matter depends on whether native FBXO34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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