FBXO41

Protein identityUniProt · HPA

UniProt accession

Q8TF61

Gene

FBXO41

Ensembl

ENSG00000163013

Chromosome

2

Canonical length

875 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

875 residues, UniProt reviewed canonical sequence.

>Q8TF61|FBXO41
     1  MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA
    61  ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP AAPHLLHHHH HHAPLAHFPG
   121  DLVPASLPCE ELAEPGLVPA AAARYALREI EIPLGELFAR KSVASSACST PPPGPGPGPC
   181  PGPASASPAS PSPADVAYEE GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE
   241  LERKAAELET ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
   301  QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC GSTPSASLGR
   361  GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS TGASSRVPAA SQSSGCYDSD
   421  SLELPRPEEG APEDSGPGGL GTRAQAANGG SERSQPPRSS GLRRQAIQNW QRRPRRHSTE
   481  GEEGDVSDVG SRTTESEAEG PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS
   541  RSNEVISPEI LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
   601  SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES LLKAAGGNLL
   661  ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH EVIWALGAGC REIVSLQVAP
   721  LHPCQQPTRF SNRCLQMIGR CWPHLRALGV GGAGCGVQGL ASLARNCMRL QVLELDHVSE
   781  ITQEVAAEVC REGLKGLEML VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS
   841  PEAQKLFEDM VTKLQALRRR PGFSKILHIK VEGGC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.21

gnomAD pLI

1

gnomAD missense Z

1.85

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chemical synaptic transmission
• dentate gyrus development
• gene expression
• neuron maturation
• neuron migration

Cellular components

• cytosol
• synapse

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• Leucine-rich repeat domain superfamily
• F-box-like domain superfamily
• Genomic Stability and Neuronal Morphogenesis Regulator
• FBX41/ZN365, C2H2-type zinc finger
• F-box-like
• F-box only protein 41 C2H2 zinc finger

KeywordsUniProt

• Coiled coil
• Methylation
• Phosphoprotein
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• SKP1