Seroatlas · Human Serome Atlas

FBXL12

F-box/LRR-repeat protein 12

Also known as: Fbl12, FLJ20188, FXL12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NXK8
Gene: FBXL12
Ensembl: ENSG00000127452
Chromosome: 19
Canonical length: 326 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q9NXK8|FBXL12
     1  MATLVELPDS VLLEIFSYLP VRDRIRISRV CHRWKRLVDD RWLWRHVDLT LYTMRPKVMW
    61  HLLRRYMASR LHSLRMGGYL FSGSQAPQLS PALLRALGQK CPNLKRLCLH VADLSMVPIT
   121  SLPSTLRTLE LHSCEISMAW LHKQQDPTVL PLLECIVLDR VPAFRDEHLQ GLTRFRALRS
   181  LVLGGTYRVT ETGLDAGLQE LSYLQRLEVL GCTLSADSTL LAISRHLRDV RKIRLTVRGL
   241  SAPGLAVLEG MPALESLCLQ GPLVTPEMPS PTEILSSCLT MPKLRVLELQ GLGWEGQEAE
   301  KILCKGLPHC MVIVRACPKE SMDWWM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

thymus: 41 nTPM
bone marrow: 26 nTPM
urinary bladder: 23 nTPM
ovary: 23 nTPM
blood vessel: 22 nTPM
endometrium: 22 nTPM

Single-cell type

syncytiotrophoblasts: 84 nCPM
enterocytes: 75 nCPM
cytotrophoblasts: 53 nCPM
migrating cytotrophoblasts: 47 nCPM
decidual stromal cells: 44 nCPM
urothelial cells: 43 nCPM

Immune cell

eosinophil: 37 nTPM
basophil: 34 nTPM
NK-cell: 31 nTPM
naive B-cell: 24 nTPM
T-reg: 22 nTPM
plasmacytoid DC: 22 nTPM

Brain region

cerebellum: 25 nTPM
white matter: 23 nTPM
medulla oblongata: 23 nTPM
cerebral cortex: 22 nTPM
thalamus: 22 nTPM
pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0.04
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL12 as an antibody target. Whether an autoantibody or antibody against FBXL12 could matter depends on whether native FBXL12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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