Seroatlas · Human Serome Atlas

CACYBP

Calcyclin-binding protein

Also known as: CYBP_HUMAN, S100A6BP, SIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HB71
Gene: CACYBP
Ensembl: ENSG00000116161
Chromosome: 1
Canonical length: 228 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q9HB71|CACYBP
     1  MASEELQKDL EEVKVLLEKA TRKRVRDALT AEKSKIETEI KNKMQQKSQK KAELLDNEKP
    61  AAVVAPITTG YTVKISNYGW DQSDKFVKIY ITLTGVHQVP TENVQVHFTE RSFDLLVKNL
   121  NGKSYSMIVN NLLKPISVEG SSKKVKTDTV LILCRKKVEN TRWDYLTQVE KECKEKEKPS
   181  YDTETDPSEG LMNVLKKIYE DGDDDMKRTI NKAWVESREK QAKGDTEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACYBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 74 nTPM
cerebellum: 62 nTPM
hypothalamus: 59 nTPM
basal ganglia: 59 nTPM
hippocampal formation: 57 nTPM
amygdala: 56 nTPM

Single-cell type

oocytes: 548 nCPM
migrating cytotrophoblasts: 352 nCPM
megakaryocytes: 321 nCPM
extravillous trophoblasts: 318 nCPM
late primary spermatocytes: 316 nCPM
cytotrophoblasts: 279 nCPM

Immune cell

non-classical monocyte: 56 nTPM
T-reg: 49 nTPM
total PBMC: 46 nTPM
naive CD4 T-cell: 45 nTPM
NK-cell: 44 nTPM
memory B-cell: 43 nTPM

Brain region

cerebral cortex: 132 nTPM
white matter: 97 nTPM
pons: 88 nTPM
cerebellum: 88 nTPM
hypothalamus: 83 nTPM
hippocampal formation: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.92
gnomAD missense Z: 1.14
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CS domain
SGS domain
HSP20-like chaperone
CS domain
SGS domain
Siah interacting protein, N-terminal
Calcyclin-binding protein, N-terminal
Calcyclin-binding Protein, CS domain
Calcyclin-binding ubiquitin ligase bridge
Siah interacting protein, N terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACYBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACYBP as an antibody target. Whether an autoantibody or antibody against CACYBP could matter depends on whether native CACYBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACYBP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CACYBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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