Seroatlas · Human Serome Atlas

FBXL13

F-box and leucine-rich repeat protein 13

Also known as: CFAP169, DRC6, Fbl13, FXL13_HUMAN, MGC21636

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NEE6
Gene
FBXL13
Ensembl
ENSG00000161040
Chromosome
7
Canonical length
735 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

735 residues, UniProt reviewed canonical sequence.

>Q8NEE6|FBXL13
     1  MTPELMIKAC SFYTGHLVKT HFCTWRDIAR TNENVVLAEK MNRAVTCYNF RLQKSVFHHW
    61  HSYMEDQKEK LKNILLRIQQ IIYCHKLTII LTKWRNTARH KSKKKEDELI LKHELQLKKW
   121  KNRLILKRAA AEESNFPERS SSEVFLVDET LKCDISLLPE RAILQIFFYL SLKDVIICGQ
   181  VNHAWMLMTQ LNSLWNAIDF SSVKNVIPDK YIVSTLQRWR LNVLRLNFRG CLLRPKTFRS
   241  VSHCRNLQEL NVSDCPTFTD ESMRHISEGC PGVLCLNLSN TTITNRTMRL LPRHFHNLQN
   301  LSLAYCRRFT DKGLQYLNLG NGCHKLIYLD LSGCTQISVQ GFRYIANSCT GIMHLTINDM
   361  PTLTDNCVKA LVEKCSRITS LVFTGAPHIS DCTFRALSAC KLRKIRFEGN KRVTDASFKF
   421  IDKNYPNLSH IYMADCKGIT DSSLRSLSPL KQLTVLNLAN CVRIGDMGLK QFLDGPASMR
   481  IRELNLSNCV RLSDASVMKL SERCPNLNYL SLRNCEHLTA QGIGYIVNIF SLVSIDLSGT
   541  DISNEGLNVL SRHKKLKELS VSECYRITDD GIQAFCKSSL ILEHLDVSYC SQLSDMIIKA
   601  LAIYCINLTS LSIAGCPKIT DSAMEMLSAK CHYLHILDIS GCVLLTDQIL EDLQIGCKQL
   661  RILKMQYCTN ISKKAAQRMS SKVQQQEYNT NDPPRWFGYD REGNPVTELD NITSSKGALE
   721  LTVKKSTYSS EDQAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
4.8 nTPM

Expression across tissuesHPA

Tissue

  • stomach: 4.8 nTPM
  • testis: 3.7 nTPM
  • retina: 2.5 nTPM
  • fallopian tube: 2.2 nTPM
  • adrenal gland: 1.5 nTPM
  • choroid plexus: 1.4 nTPM

Single-cell type

  • late spermatids: 748 nCPM
  • neutrophils: 625 nCPM
  • respiratory ciliated cells: 468 nCPM
  • ependymal cells: 459 nCPM
  • fallopian tube ciliated cells: 328 nCPM
  • epicardial cells: 293 nCPM

Immune cell

  • neutrophil: 57 nTPM
  • eosinophil: 15 nTPM
  • basophil: 0.6 nTPM
  • naive CD8 T-cell: 0.3 nTPM
  • intermediate monocyte: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • midbrain: 7.4 nTPM
  • medulla oblongata: 7.3 nTPM
  • white matter: 6.8 nTPM
  • cerebral cortex: 6.7 nTPM
  • cerebellum: 6.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.55
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL13 as an antibody target. Whether an autoantibody or antibody against FBXL13 could matter depends on whether native FBXL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXL13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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