Seroatlas · Human Serome Atlas

FBXL22

F-box and leucine-rich protein 22

Also known as: Fbl22, FLJ39626, FXL22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P050
Gene: FBXL22
Ensembl: ENSG00000197361
Chromosome: 15
Canonical length: 247 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q6P050|FBXL22
     1  MWPLLTMHIT QLNRECLLHL FSFLDKDSRK SLARTCSQLH DVFEDPALWS LLHFRSLTEL
    61  QKDNFLLGPA LRSLSICWHS SRVQVCSIED WLKSAFQRSI CSRHESLVND FLLRVCDRLS
   121  AVRSPRRREA PAPSSGTPIA VGPKSPRWGG PDHSEFADLR SGVTGARAAA RRGLGSLRAE
   181  RPSETPPAPG VSWGPPPPGA PVVISVKQEE GKQGRTGRRS HRAAPPCGFA RTRVCPPTFP
   241  GADAFPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

colon: 56 nTPM
endometrium: 50 nTPM
blood vessel: 31 nTPM
urinary bladder: 29 nTPM
seminal vesicle: 28 nTPM
smooth muscle: 27 nTPM

Single-cell type

smooth muscle cells: 86 nCPM
epididymal principal cells: 38 nCPM
cardiomyocytes: 30 nCPM
breast myoepithelial cells: 22 nCPM
vascular smooth muscle cells: 19 nCPM
oocytes: 18 nCPM

Immune cell

plasmacytoid DC: 1.6 nTPM
naive CD4 T-cell: 1 nTPM
memory B-cell: 0.7 nTPM
memory CD8 T-cell: 0.7 nTPM
NK-cell: 0.7 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

cerebellum: 8.9 nTPM
basal ganglia: 7.2 nTPM
cerebral cortex: 7.1 nTPM
hypothalamus: 7.1 nTPM
amygdala: 6.5 nTPM
hippocampal formation: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: -0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL22 as an antibody target. Whether an autoantibody or antibody against FBXL22 could matter depends on whether native FBXL22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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