Seroatlas · Human Serome Atlas

FBXO33

F-box only protein 33

Also known as: Fbx33, FBX33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z6M2
Gene
FBXO33
Ensembl
ENSG00000165355
Chromosome
14
Canonical length
555 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

555 residues, UniProt reviewed canonical sequence.

>Q7Z6M2|FBXO33
     1  MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA
    61  LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA
   121  EQPRLEFLMR KCGWFVRELR VEFAAENYLS GGGPGDGGGA DTGTGGEEVE ALQLSARWLE
   181  VLRTYLELVL CVLVSIRNNR NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ
   241  LFEEILSNSR QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV
   301  ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS LDNMPNDEHW
   361  KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD SYITCVSGAI VDLISRQYDK
   421  FLTHFILMND VIDTSGFPDL SDNRNEDPLV LLAWRCTKLS LLAIHGYTVW AHNLIAIARL
   481  RGSDLKVLEV TEESIDFDQG ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP
   541  NRHFYREMQS FSEDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • choroid plexus: 16 nTPM
  • parathyroid gland: 13 nTPM
  • testis: 13 nTPM
  • thyroid gland: 11 nTPM
  • thymus: 11 nTPM

Single-cell type

  • neutrophils: 493 nCPM
  • neutrophil progenitors: 179 nCPM
  • b-cells: 137 nCPM
  • nk-cells: 137 nCPM
  • somatotrophs: 136 nCPM
  • t-cells: 135 nCPM

Immune cell

  • neutrophil: 4 nTPM
  • NK-cell: 2.8 nTPM
  • naive CD4 T-cell: 2.2 nTPM
  • naive CD8 T-cell: 2.1 nTPM
  • eosinophil: 1.9 nTPM
  • memory CD8 T-cell: 1.7 nTPM

Brain region

  • choroid plexus: 31 nTPM
  • cerebral cortex: 30 nTPM
  • hippocampal formation: 27 nTPM
  • pons: 23 nTPM
  • hypothalamus: 23 nTPM
  • medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
0.89
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO33 as an antibody target. Whether an autoantibody or antibody against FBXO33 could matter depends on whether native FBXO33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXO33. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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