Seroatlas · Human Serome Atlas

FBXL6

F-box/LRR-repeat protein 6

Also known as: FBL6, FBXL6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N531
Gene: FBXL6
Ensembl: ENSG00000182325
Chromosome: 8
Canonical length: 539 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q8N531|FBXL6
     1  MAAPASRQVR RRARAAPRPR SAEDWWWDRL APRGSGYHLL QSDSMLLVLS EPGPARPRAQ
    61  RRASRRTPRQ PPRGPSAAAK PKAGLRSEAA AAPAPAPAPT PTPEEGPDAG WGDRIPLEIL
   121  VQIFGLLVAA DGPMPFLGRA ARVCRRWQEA ASQPALWHTV TLSSPLVGRP AKGGVKAEKK
   181  LLASLEWLMP NRFSQLQRLT LIHWKSQVHP VLKLVGECCP RLTFLKLSGC HGVTADALVM
   241  LAKACCQLHS LDLQHSMVES TAVVSFLEEA GSRMRKLWLT YSSQTTAILG ALLGSCCPQL
   301  QVLEVSTGIN RNSIPLQLPV EALQKGCPQL QVLRLLNLMW LPKPPGRGVA PGPGFPSLEE
   361  LCLASSTCNF VSNEVLGRLL HGSPNLRLLD LRGCARITPA GLQDLPCREL EQLHLGLYGT
   421  SDRLTLAKEG SPFLTQKWCH TLRELDLSGQ GFSEKDLEQA LAAFLSTPGG SHPALCSLNL
   481  RGTRVTPSTV SSVISGCPGL LYLNLESCRC LPRGLKRAYR GLEEVQWCLE QLLTSPSPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

liver: 11 nTPM
pancreas: 8.1 nTPM
colon: 7.9 nTPM
small intestine: 7.7 nTPM
esophagus: 7.2 nTPM
spleen: 7 nTPM

Single-cell type

enterocytes: 31 nCPM
breast lactating cells: 22 nCPM
brain excitatory neurons: 16 nCPM
bergmann glia: 14 nCPM
enteric transient amplifying cells: 13 nCPM
other brain neurons: 13 nCPM

Immune cell

non-classical monocyte: 1.6 nTPM
plasmacytoid DC: 0.7 nTPM
eosinophil: 0.6 nTPM
gdT-cell: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
MAIT T-cell: 0.3 nTPM

Brain region

thalamus: 1.9 nTPM
cerebral cortex: 1.7 nTPM
choroid plexus: 1.7 nTPM
cerebellum: 1.6 nTPM
medulla oblongata: 1.6 nTPM
pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: -1.08
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-protein transferase activity

Cellular components

SCF ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat
F-box domain
Leucine-rich repeat, cysteine-containing subtype
Leucine-rich repeat domain superfamily
F-box-like domain superfamily
F-box-like
Leucine Rich repeat
F-box/LRR-repeat protein 6, F-box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXL6 as an antibody target. Whether an autoantibody or antibody against FBXL6 could matter depends on whether native FBXL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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