CDCA3
Cell division cycle-associated protein 3
Also known as: CDCA3_HUMAN, GRCC8, TOME-1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q99618
- Gene
- CDCA3
- Ensembl
- ENSG00000111665
- Chromosome
- 12
- Canonical length
- 268 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
268 residues, UniProt reviewed canonical sequence.
>Q99618|CDCA3
1 MGSAKSVPVT PARPPPHNKH LARVADPRSP SAGILRTPIQ VESSPQPGLP AGEQLEGLKH
61 AQDSDPRSPT LGIARTPMKT SSGDPPSPLV KQLSEVFETE DSKSNLPPEP VLPPEAPLSS
121 ELDLPLGTQL SVEEQMPPWN QTEFPSKQVF SKEEARQPTE TPVASQSSDK PSRDPETPRS
181 SGSMRNRWKP NSSKVLGRSP LTILQDDNSP GTLTLRQGKR PSPLSENVSE LKEGAILGTG
241 RLLKTGGRAW EQGQDHDKEN QHFPLVESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDCA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.71
- Highest tissue expression
- 62 nTPM
Expression across tissuesHPA
Tissue
- retina: 62 nTPM
- thymus: 28 nTPM
- tonsil: 22 nTPM
- testis: 21 nTPM
- duodenum: 20 nTPM
- small intestine: 17 nTPM
Single-cell type
- late primary spermatocytes: 93 nCPM
- extravillous trophoblasts: 84 nCPM
- cardiomyocytes: 68 nCPM
- enterocytes: 60 nCPM
- migrating cytotrophoblasts: 52 nCPM
- enteric transient amplifying cells: 49 nCPM
Immune cell
- T-reg: 4.3 nTPM
- plasmacytoid DC: 1.1 nTPM
- memory CD8 T-cell: 0.8 nTPM
- memory B-cell: 0.7 nTPM
- memory CD4 T-cell: 0.7 nTPM
- total PBMC: 0.5 nTPM
Brain region
- cerebellum: 1.9 nTPM
- cerebral cortex: 1.8 nTPM
- basal ganglia: 1.3 nTPM
- pons: 1.2 nTPM
- hippocampal formation: 1.1 nTPM
- hypothalamus: 1.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.5
- gnomAD pLI
- 0.69
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- -0.35
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cell division cycle-associated protein 3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDCA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDCA3 as an antibody target. Whether an autoantibody or antibody against CDCA3 could matter depends on whether native CDCA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDCA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDCA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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