FBXO22

Protein identityUniProt · HPA

UniProt accession

Q8NEZ5

Gene

FBXO22

Ensembl

ENSG00000167196

Chromosome

15

Canonical length

403 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>Q8NEZ5|FBXO22
     1  MEPVGCCGEC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR LWRECVRRVL
    61  RTHRSVTWIS AGLAEAGHLE GHCLVRVVAE ELENVRILPH TVLYMADSET FISLEECRGH
   121  KRARKRTSME TALALEKLFP KQCQVLGIVT PGIVVTPMGS GSNRPQEIEI GESGFALLFP
   181  QIEGIKIQPF HFIKDPKNLT LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV
   241  STFSDMNIIL AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
   301  TAEAAMQRLK AANIPEHNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP SVPLFGFFGN
   361  GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG SSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

20 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO22.

Disease | AllUniProt

Conditions FBXO22 is implicated in, by any mechanism.

• Tayoun-Maawali syndrome (TYMAS) MIM:621184

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Tayoun-Maawali syndrome
• Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.3

gnomAD pLI

0.98

gnomAD missense Z

0.84

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to starvation
• nucleocytoplasmic transport
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• proteasome-mediated ubiquitin-dependent protein catabolic process
• protein modification process
• protein polyubiquitination
• regulation of skeletal muscle fiber development
• ubiquitin-dependent protein catabolic process

Molecular functions

• ubiquitin-protein transferase activity

Cellular components

• cytosol
• nucleus
• Z disc

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• F-box-like domain superfamily
• F-box domain
• FIST, C-domain
• FIST C domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Nucleus
• Phosphoprotein
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXO22 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• MTOR
• SKP1
• TP53
• KDM4A