Seroatlas · Human Serome Atlas

CEP68

Centrosomal protein of 68 kDa

Also known as: CEP68_HUMAN, KIAA0582

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q76N32
Gene: CEP68
Ensembl: ENSG00000011523
Chromosome: 2
Canonical length: 757 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions,Centriolar satellite,Basal body,Cytosol

OverviewNCBI Gene

Enables protein domain specific binding activity and protein kinase binding activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in several cellular components, including cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

757 residues, UniProt reviewed canonical sequence.

>Q76N32|CEP68
     1  MALGEEKAEA EASEDTKAQS YGRGSCRERE LDIPGPMSGE QPPRLEAEGG LISPVWGAEG
    61  IPAPTCWIGT DPGGPSRAHQ PQASDANREP VAERSEPALS GLPPATMGSG DLLLSGESQV
   121  EKTKLSSSEE FPQTLSLPRT TTICSGHDAD TEDDPSLADL PQALDLSQQP HSSGLSCLSQ
   181  WKSVLSPGSA AQPSSCSISA SSTGSSLQGH QERAEPRGGS LAKVSSSLEP VVPQEPSSVV
   241  GLGPRPQWSP QPVFSGGDAS GLGRRRLSFQ AEYWACVLPD SLPPSPDRHS PLWNPNKEYE
   301  DLLDYTYPLR PGPQLPKHLD SRVPADPVLQ DSGVDLDSFS VSPASTLKSP TNVSPNCPPA
   361  EATALPFSGP REPSLKQWPS RVPQKQGGMG LASWSQLAST PRAPGSRDAR WERREPALRG
   421  AKDRLTIGKH LDMGSPQLRT RDRGWPSPRP EREKRTSQSA RRPTCTESRW KSEEEVESDD
   481  EYLALPARLT QVSSLVSYLG SISTLVTLPT GDIKGQSPLE VSDSDGPASF PSSSSQSQLP
   541  PGAALQGSGD PEGQNPCFLR SFVRAHDSAG EGSLGSSQAL GVSSGLLKTR PSLPARLDRW
   601  PFSDPDVEGQ LPRKGGEQGK ESLVQCVKTF CCQLEELICW LYNVADVTDH GTAARSNLTS
   661  LKSSLQLYRQ FKKDIDEHQS LTESVLQKGE ILLQCLLENT PVLEDVLGRI AKQSGELESH
   721  ADRLYDSILA SLDMLAGCTL IPDKKPMAAM EHPCEGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 23 nTPM
tongue: 22 nTPM
cerebellum: 16 nTPM
ovary: 15 nTPM
adipose tissue: 14 nTPM
cerebral cortex: 14 nTPM

Single-cell type

epicardial cells: 177 nCPM
lymphatic endothelial cells: 96 nCPM
neutrophils: 92 nCPM
vascular endothelial cells: 88 nCPM
syncytiotrophoblasts: 82 nCPM
respiratory basal cells: 80 nCPM

Immune cell

naive CD4 T-cell: 9 nTPM
plasmacytoid DC: 8.8 nTPM
non-classical monocyte: 7.5 nTPM
naive CD8 T-cell: 5.5 nTPM
memory CD4 T-cell: 5.3 nTPM
NK-cell: 4.8 nTPM

Brain region

cerebral cortex: 31 nTPM
basal ganglia: 29 nTPM
white matter: 28 nTPM
cerebellum: 28 nTPM
amygdala: 27 nTPM
thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.52
gnomAD missense Z: -0.63
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP68 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP68 as an antibody target. Whether an autoantibody or antibody against CEP68 could matter depends on whether native CEP68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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