FBXL18

Protein identityUniProt · HPA

UniProt accession

Q96ME1

Gene

FBXL18

Ensembl

ENSG00000155034

Chromosome

7

Canonical length

718 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q96ME1|FBXL18
     1  MASSGEDISN DDDDMHPAAA GMADGVHLLG FSDEILLHIL SHVPSTDLIL NVRRTCRKLA
    61  ALCLDKSLIH TVLLQKDYQA SEDKVRQLVK EIGREIQQLS MAGCYWLPGS TVEHVARCRS
   121  LVKVNLSGCH LTSLRLSKML SALQHLRSLA IDVSPGFDAS QLSSECKATL SRVRELKQTL
   181  FTPSYGVVPC CTSLEKLLLY FEILDRTREG AILSGQLMVG QSNVPHYQNL RVFYARLAPG
   241  YINQEVVRLY LAVLSDRTPQ NLHAFLISVP GSFAESGATK NLLDSMARNV VLDALQLPKS
   301  WLNGSSLLQH MKFNNPFYFS FSRCTLSGGH LIQQVINGGK DLRSLASLNL SGCVHCLSPD
   361  SLLRKAEDDI DSSILETLVA SCCNLRHLNL SAAHHHSSEG LGRHLCQLLA RLRHLRSLSL
   421  PVCSVADSAP RADRAPAQPA MHAVPRGFGK KVRVGVQSCP SPFSGQACPQ PSSVFWSLLK
   481  NLPFLEHLEL IGSNFSSAMP RNEPAIRNSL PPCSRAQSVG DSEVAAIGQL AFLRHLTLAQ
   541  LPSVLTGSGL VNIGLQCQQL RSLSLANLGM MGKVVYMPAL SDMLKHCKRL RDLRLEQPYF
   601  SANAQFFQAL SQCPSLQRLC LVSRSGTLQP DAVLAFMARC LQVVMCHLFT GESLATCKSL
   661  QQSLLRSFQA ERPALNVVIF PLLHEGLTDV IRDVPLVHLD EITLFKSRVA EEPPNLWW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXL18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

7.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.88

gnomAD pLI

0

gnomAD missense Z

1.8

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• F-box domain
• Leucine-rich repeat domain superfamily
• F-box-like domain superfamily
• F-box-like
• F-box/LRR-repeat protein 18, LRR domain
• F-box/LRR-repeat protein 18, F-box domain
• F-box/LRR-repeat protein 18, LRR

KeywordsUniProt

• Leucine-rich repeat
• Repeat
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of FBXL18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL1
• SKP1
• WWP2