Seroatlas · Human Serome Atlas

RRP15

RRP15-like protein

Also known as: CGI-115, KIAA0507, RRP15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B9
Gene: RRP15
Ensembl: ENSG00000067533
Chromosome: 1
Canonical length: 282 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli rim,Mitotic chromosome,Mitochondria

OverviewNCBI Gene

This gene encodes a protein that co-purifies with human nucleoli. A similar protein in budding yeast is a component of pre-60S ribosomal particles, and is required for the early maturation steps of the 60S subunit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q9Y3B9|RRP15
     1  MAAAAPDSRV SEEENLKKTP KKKMKMVTGA VASVLEDEAT DTSDSEGSCG SEKDHFYSDD
    61  DAIEADSEGD AEPCDKENEN DGESSVGTNM GWADAMAKVL NKKTPESKPT ILVKNKKLEK
   121  EKEKLKQERL EKIKQRDKRL EWEMMCRVKP DVVQDKETER NLQRIATRGV VQLFNAVQKH
   181  QKNVDEKVKE AGSSMRKRAK LISTVSKKDF ISVLRGMDGS TNETASSRKK PKAKQTEVKS
   241  EEGPGWTILR DDFMMGASMK DWDKESDGPD DSRPESASDS DT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRP15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.1 nTPM
tongue: 7.2 nTPM
heart muscle: 4.6 nTPM
breast: 4.4 nTPM
parathyroid gland: 4.2 nTPM
bone marrow: 3.9 nTPM

Single-cell type

erythrocyte progenitors: 101 nCPM
differentiating spermatogonia: 100 nCPM
megakaryocytes: 87 nCPM
basal keratinocytes: 86 nCPM
alveolar cells type 1: 86 nCPM
extravillous trophoblasts: 74 nCPM

Immune cell

naive CD4 T-cell: 2.6 nTPM
naive CD8 T-cell: 2.6 nTPM
memory B-cell: 2.4 nTPM
MAIT T-cell: 2.3 nTPM
naive B-cell: 2.3 nTPM
memory CD4 T-cell: 2 nTPM

Brain region

cerebellum: 7.2 nTPM
cerebral cortex: 6.5 nTPM
midbrain: 6.3 nTPM
hypothalamus: 5.8 nTPM
white matter: 5.8 nTPM
basal ganglia: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.87
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

large subunit precursor
preribosome

Protein domainsUniProt · Pfam · InterPro

Ribosomal RNA-processing protein 15
Rrp15p

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RRP15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RRP15 as an antibody target. Whether an autoantibody or antibody against RRP15 could matter depends on whether native RRP15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RRP15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RRP15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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