Seroatlas · Human Serome Atlas

AAMP

Angio-associated migratory cell protein

Also known as: AAMP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13685
Gene
AAMP
Ensembl
ENSG00000127837
Chromosome
2
Canonical length
434 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

434 residues, UniProt reviewed canonical sequence.

>Q13685|AAMP
     1  MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG
    61  NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR
   121  LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM
   181  EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR
   241  IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP
   301  ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG
   361  IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG
   421  DHKAKVFCVQ RPDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AAMP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
89 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 89 nTPM
  • stomach: 88 nTPM
  • choroid plexus: 82 nTPM
  • ovary: 80 nTPM
  • liver: 77 nTPM
  • skin: 76 nTPM

Single-cell type

  • syncytiotrophoblasts: 240 nCPM
  • cytotrophoblasts: 191 nCPM
  • migrating cytotrophoblasts: 187 nCPM
  • esophageal suprabasal cells: 175 nCPM
  • esophageal basal cells: 174 nCPM
  • decidual stromal cells: 169 nCPM

Immune cell

  • non-classical monocyte: 212 nTPM
  • intermediate monocyte: 209 nTPM
  • myeloid DC: 192 nTPM
  • total PBMC: 179 nTPM
  • classical monocyte: 167 nTPM
  • NK-cell: 115 nTPM

Brain region

  • white matter: 58 nTPM
  • medulla oblongata: 57 nTPM
  • spinal cord: 54 nTPM
  • hypothalamus: 54 nTPM
  • thalamus: 54 nTPM
  • midbrain: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.76
gnomAD missense Z
1.75
DepMap mean gene effect
-1.18
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AAMP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AAMP as an antibody target. Whether an autoantibody or antibody against AAMP could matter depends on whether native AAMP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AAMP is annotated at the cell surface, where native AAMP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AAMP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AAMP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...