Seroatlas · Human Serome Atlas

RPL10L

Ribosomal protein uL16-like

Also known as: RL10L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96L21
Gene
RPL10L
Ensembl
ENSG00000165496
Chromosome
14
Canonical length
214 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

214 residues, UniProt reviewed canonical sequence.

>Q96L21|RPL10L
     1  MGRRPARCYR YCKNKPYPKS RFCRGVPDAK IRIFDLGRKK AKVDEFPLGG HMVSDEYEQL
    61  SSEALEAARI CANKYMVKSC GRDGFHMRVR LHPFHVIRIN KMLSCAGADR LQTGMRGAFG
   121  KPQGTVARVH IGQVIMSIRT KLQNEEHVIE ALRRAKFKFP GRQKIHISKK WGFTKFNADE
   181  FEDMVAKKCL IPDGCGVKYV PSHGPLDKWR VLHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL10L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • testis: 92 nTPM
  • rectum: 2.5 nTPM
  • colon: 2.3 nTPM
  • duodenum: 0.6 nTPM
  • appendix: 0.2 nTPM
  • small intestine: 0.2 nTPM

Single-cell type

  • late primary spermatocytes: 892 nCPM
  • early spermatids: 527 nCPM
  • late spermatids: 280 nCPM
  • early primary spermatocytes: 35 nCPM
  • undifferentiated spermatogonia: 12 nCPM
  • differentiating spermatogonia: 10 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM
  • thalamus: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL10L.

Disease | AllUniProt

Conditions RPL10L is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0.01
gnomAD missense Z
-0.25
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL10L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL10L as an antibody target. Whether an autoantibody or antibody against RPL10L could matter depends on whether native RPL10L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL10L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL10L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPL10L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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