Seroatlas · Human Serome Atlas

MRPL38

Large ribosomal subunit protein mL38

Also known as: HSPC262, MGC4810, MRP-L3, RM38_HUMAN, RPML3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DV4
Gene: MRPL38
Ensembl: ENSG00000204316
Chromosome: 17
Canonical length: 380 aa
Protein class: Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>Q96DV4|MRPL38
     1  MAAPWWRAAL CECRRWRGFS TSAVLGRRTP PLGPMPNSDI DLSNLERLEK YRSFDRYRRR
    61  AEQEAQAPHW WRTYREYFGE KTDPKEKIDI GLPPPKVSRT QQLLERKQAI QELRANVEEE
   121  RAARLRTASV PLDAVRAEWE RTCGPYHKQR LAEYYGLYRD LFHGATFVPR VPLHVAYAVG
   181  EDDLMPVYCG NEVTPTEAAQ APEVTYEAEE GSLWTLLLTS LDGHLLEPDA EYLHWLLTNI
   241  PGNRVAEGQV TCPYLPPFPA RGSGIHRLAF LLFKQDQPID FSEDARPSPC YQLAQRTFRT
   301  FDFYKKHQET MTPAGLSFFQ CRWDDSVTYI FHQLLDMREP VFEFVRPPPY HPKQKRFPHR
   361  QPLRYLDRYR DSHEPTYGIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 137 nTPM
heart muscle: 80 nTPM
tongue: 79 nTPM
liver: 76 nTPM
adrenal gland: 54 nTPM
kidney: 51 nTPM

Single-cell type

bergmann glia: 25 nCPM
oligodendrocytes: 25 nCPM
astrocytes: 23 nCPM
ependymal cells: 22 nCPM
other brain neurons: 22 nCPM
brain excitatory neurons: 18 nCPM

Immune cell

naive B-cell: 114 nTPM
myeloid DC: 107 nTPM
memory B-cell: 102 nTPM
NK-cell: 96 nTPM
T-reg: 94 nTPM
memory CD4 T-cell: 86 nTPM

Brain region

thalamus: 41 nTPM
cerebellum: 39 nTPM
pons: 39 nTPM
medulla oblongata: 38 nTPM
cerebral cortex: 37 nTPM
spinal cord: 36 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.6
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

mitochondrial translation

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MRPL38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MRPL38 as an antibody target. Whether an autoantibody or antibody against MRPL38 could matter depends on whether native MRPL38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MRPL38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MRPL38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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