Seroatlas · Human Serome Atlas

CRK

Adapter molecule crk

Also known as: CRK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P46108
Gene
CRK
Ensembl
ENSG00000167193
Chromosome
17
Canonical length
304 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Actin filaments,Basal body
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>P46108|CRK
     1  MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY
    61  IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR
   121  SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG
   181  MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA
   241  RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD
   301  EDFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CRK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • liver: 47 nTPM
  • adipose tissue: 45 nTPM
  • placenta: 40 nTPM
  • tongue: 35 nTPM
  • blood vessel: 35 nTPM
  • thyroid gland: 34 nTPM

Single-cell type

  • choroid plexus epithelial cells: 105 nCPM
  • microglia: 71 nCPM
  • proximal tubule cells: 69 nCPM
  • papillary tip epithelial cells: 67 nCPM
  • renal collecting duct intercalated cells: 67 nCPM
  • renal connecting tubule cells: 62 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • basophil: 6.2 nTPM
  • eosinophil: 5.3 nTPM
  • naive B-cell: 5.2 nTPM
  • non-classical monocyte: 4.4 nTPM
  • myeloid DC: 4.3 nTPM

Brain region

  • thalamus: 48 nTPM
  • spinal cord: 46 nTPM
  • midbrain: 45 nTPM
  • medulla oblongata: 45 nTPM
  • pons: 44 nTPM
  • white matter: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CRK.

Disease | ImmuneIEDB

Conditions an epitope on CRK was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.33
gnomAD pLI
0.96
gnomAD missense Z
2.37
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CRK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CRK as an antibody target. Whether an autoantibody or antibody against CRK could matter depends on whether native CRK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CRK is annotated at the cell surface, where native CRK is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CRK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CRK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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