Seroatlas · Human Serome Atlas

PSMG2

Proteasome assembly chaperone 2

Also known as: CLAST3, HCCA3, HsT1707, MDS003, MGC15092, PAC2, PSMG2_HUMAN, TNFSF5IP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969U7
Gene: PSMG2
Ensembl: ENSG00000128789
Chromosome: 18
Canonical length: 264 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in nucleus. Part of protein folding chaperone complex. Implicated in proteosome-associated autoinflammatory syndrome 4. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q969U7|PSMG2
     1  MFVPCGESAP DLAGFTLLMP AVSVGNVGQL AMDLIISTLN MSKIGYFYTD CLVPMVGNNP
    61  YATTEGNSTE LSINAEVYSL PSRKLVALQL RSIFIKYKSK PFCEKLLSWV KSSGCARVIV
   121  LSSSHSYQRN DLQLRSTPFR YLLTPSMQKS VQNKIKSLNW EEMEKSRCIP EIDDSEFCIR
   181  IPGGGITKTL YDESCSKEIQ MAVLLKFVSE GDNIPDALGL VEYLNEWLQI LKPLSDDPTV
   241  SASRWKIPSS WRLLFGSGLP PALF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

testis: 82 nTPM
bone marrow: 70 nTPM
blood vessel: 68 nTPM
epididymis: 63 nTPM
adipose tissue: 62 nTPM
ovary: 62 nTPM

Single-cell type

late primary spermatocytes: 797 nCPM
early spermatids: 529 nCPM
esophageal apical cells: 304 nCPM
oocytes: 272 nCPM
differentiating spermatogonia: 249 nCPM
migrating cytotrophoblasts: 218 nCPM

Immune cell

non-classical monocyte: 98 nTPM
T-reg: 92 nTPM
intermediate monocyte: 85 nTPM
total PBMC: 78 nTPM
classical monocyte: 78 nTPM
eosinophil: 76 nTPM

Brain region

cerebellum: 47 nTPM
white matter: 39 nTPM
cerebral cortex: 38 nTPM
basal ganglia: 35 nTPM
pons: 34 nTPM
medulla oblongata: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMG2.

Disease | AllUniProt

Conditions PSMG2 is implicated in, by any mechanism.

Proteasome-associated autoinflammatory syndrome 4 (PRAAS4) MIM:619183

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 248 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Proteasome-associated autoinflammatory syndrome 4

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.68
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

molecular adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proteasome assembly chaperone 2, eukaryotic
Proteasome assembly chaperone 2
Proteasome assembly chaperone 2 superfamily
PAC2 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMG2 as an antibody target. Whether an autoantibody or antibody against PSMG2 could matter depends on whether native PSMG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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