Seroatlas · Human Serome Atlas

FBXO7

F-box only protein 7

Also known as: Fbx, FBX7, FBX7_HUMAN, PARK15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3I1
Gene
FBXO7
Ensembl
ENSG00000100225
Chromosome
22
Canonical length
522 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q9Y3I1|FBXO7
     1  MRLRVRLLKR TWPLEVPETE PTLGHLRSHL RQSLLCTWGY SSNTRFTITL NYKDPLTGDE
    61  ETLASYGIVS GDLICLILQD DIPAPNIPSS TDSEHSSLQN NEQPSLATSS NQTSMQDEQP
   121  SDSFQGQAAQ SGVWNDDSML GPSQNFEAES IQDNAHMAEG TGFYPSEPML CSESVEGQVP
   181  HSLETLYQSA DCSDANDALI VLIHLLMLES GYIPQGTEAK ALSMPEKWKL SGVYKLQYMH
   241  PLCEGSSATL TCVPLGNLIV VNATLKINNE IRSVKRLQLL PESFICKEKL GENVANIYKD
   301  LQKLSRLFKD QLVYPLLAFT RQALNLPDVF GLVVLPLELK LRIFRLLDVR SVLSLSAVCR
   361  DLFTASNDPL LWRFLYLRDF RDNTVRVQDT DWKELYRKRH IQRKESPKGR FVMLLPSSTH
   421  TIPFYPNPLH PRPFPSSRLP PGIIGGEYDQ RPTLPYVGDP ISSLIPGPGE TPSQFPPLRP
   481  RFDPVGPLPG PNPILPGRGG PNDRFPFRPS RGRPTDGRLS FM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
264 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 264 nTPM
  • thyroid gland: 126 nTPM
  • spinal cord: 122 nTPM
  • liver: 120 nTPM
  • choroid plexus: 112 nTPM
  • kidney: 99 nTPM

Single-cell type

  • late spermatids: 1,098 nCPM
  • erythrocytes: 348 nCPM
  • early spermatids: 332 nCPM
  • erythrocyte progenitors: 287 nCPM
  • late primary spermatocytes: 229 nCPM
  • retinal pigment epithelial cells: 188 nCPM

Immune cell

  • basophil: 252 nTPM
  • eosinophil: 132 nTPM
  • MAIT T-cell: 102 nTPM
  • T-reg: 102 nTPM
  • NK-cell: 99 nTPM
  • total PBMC: 90 nTPM

Brain region

  • white matter: 114 nTPM
  • basal ganglia: 94 nTPM
  • medulla oblongata: 93 nTPM
  • midbrain: 90 nTPM
  • pons: 86 nTPM
  • cerebellum: 82 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FBXO7.

Disease | AllUniProt

Conditions FBXO7 is implicated in, by any mechanism.

Disease | GeneticClinVar

47 pathogenic / likely-pathogenic of 490 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
-0.44
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO7 as an antibody target. Whether an autoantibody or antibody against FBXO7 could matter depends on whether native FBXO7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FBXO7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXO7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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