Seroatlas · Human Serome Atlas

PSMG1

Proteasome assembly chaperone 1

Also known as: c21-LRP, DSCR2, LRPC21, PAC1, PSMG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95456
Gene
PSMG1
Ensembl
ENSG00000183527
Chromosome
21
Canonical length
288 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Part of protein folding chaperone complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>O95456|PSMG1
     1  MAATFFGEVV KAPCRAGTED EEEEEEGRRE TPEDREVRLQ LARKREVRLL RRQTKTSLEV
    61  SLLEKYPCSK FIIAIGNNAV AFLSSFVMNS GVWEEVGCAK LWNEWCRTTD TTHLSSTEAF
   121  CVFYHLKSNP SVFLCQCSCY VAEDQQYQWL EKVFGSCPRK NMQITILTCR HVTDYKTSES
   181  TGSLPSPFLR ALKTQNFKDS ACCPLLEQPN IVHDLPAAVL SYCQVWKIPA ILYLCYTDVM
   241  KLDLITVEAF KPILSTRSLK GLVKNIPQST EILKKLMTTN EIQSNIYT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • testis: 38 nTPM
  • bone marrow: 16 nTPM
  • liver: 15 nTPM
  • skeletal muscle: 14 nTPM
  • esophagus: 12 nTPM
  • pancreas: 10 nTPM

Single-cell type

  • late primary spermatocytes: 1,403 nCPM
  • early spermatids: 539 nCPM
  • oocytes: 350 nCPM
  • migrating cytotrophoblasts: 143 nCPM
  • early primary spermatocytes: 139 nCPM
  • esophageal basal cells: 138 nCPM

Immune cell

  • memory CD4 T-cell: 15 nTPM
  • T-reg: 14 nTPM
  • memory CD8 T-cell: 12 nTPM
  • MAIT T-cell: 12 nTPM
  • myeloid DC: 12 nTPM
  • memory B-cell: 12 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • hippocampal formation: 14 nTPM
  • basal ganglia: 12 nTPM
  • white matter: 12 nTPM
  • hypothalamus: 12 nTPM
  • pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
-0.53
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Proteasome assembly chaperone 1
  • Proteasome assembly chaperone 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMG1 as an antibody target. Whether an autoantibody or antibody against PSMG1 could matter depends on whether native PSMG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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