PSME2

Protein identityUniProt · HPA

UniProt accession

Q9UL46

Gene

PSME2

Ensembl

ENSG00000100911

Chromosome

14

Canonical length

239 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q9UL46|PSME2
     1  MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL
    61  RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL
   121  VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK
   181  ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSME2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

252 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.7

gnomAD pLI

0.02

gnomAD missense Z

1.22

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of G1/S transition of mitotic cell cycle
• regulation of proteasomal protein catabolic process

Molecular functions

• endopeptidase activator activity
• identical protein binding

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• membrane
• nucleoplasm
• proteasome activator complex
• proteasome complex

Protein domainsUniProt · Pfam · InterPro

• Proteasome activator PA28, N-terminal domain
• Proteasome activator PA28, C-terminal domain
• Proteasome activator PA28
• Proteasome activator superfamily
• Proteasome activator PA28, N-terminal domain superfamily
• Proteasome activator PA28, C-terminal domain superfamily
• Proteasome activator PA28, N-terminal
• Proteasome activator PA28, C-terminal

KeywordsUniProt

• Acetylation
• Phosphoprotein
• Proteasome

InteractionsUniProt · HPA

Protein binding partners of PSME2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PSMA1
• PSMA2
• PSMA4
• PSMA5
• PSMB1
• PSMB2
• PSMB3
• PSMB4
• PSMB7
• PSMC3
• PSME1
• SDCBP