PSME1

Protein identityUniProt · HPA

UniProt accession

Q06323

Gene

PSME1

Ensembl

ENSG00000092010

Chromosome

14

Canonical length

249 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nuclear bodies,Cytosol

Quaternary structure

Homoheptamer

OverviewNCBI Gene

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q06323|PSME1
     1  MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP
    61  LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE
   121  IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE
   181  RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP
   241  RGETKGMIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSME1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

273 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSME1.

Disease | ImmuneIEDB

Conditions an epitope on PSME1 was assayed in.

• type 1 diabetes mellitus T cell

ReferencesPubMed · IEDB

Publications for PSME1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.65

gnomAD pLI

0.13

gnomAD missense Z

0.52

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antigen processing and presentation of exogenous antigen
• regulation of G1/S transition of mitotic cell cycle
• regulation of proteasomal protein catabolic process

Molecular functions

• endopeptidase activator activity

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• nucleoplasm
• proteasome activator complex
• proteasome complex

Protein domainsUniProt · Pfam · InterPro

• Proteasome activator PA28, N-terminal domain
• Proteasome activator PA28, C-terminal domain
• Proteasome activator PA28
• Proteasome activator superfamily
• Proteasome activator PA28, N-terminal domain superfamily
• Proteasome activator PA28, C-terminal domain superfamily
• Proteasome activator PA28, N-terminal
• Proteasome activator PA28, C-terminal

KeywordsUniProt

• Proteasome

InteractionsUniProt · HPA

Protein binding partners of PSME1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PSMA1
• PSMA2
• PSMA4
• PSMA5
• PSMA6
• PSMA7
• PSMB1
• PSMB2
• PSMB3
• PSMB4
• PSMB6
• PSMB7
• PSMC3
• PSMC4
• PSMD13
• PSMD3
• PSMD4
• PSMD6
• PSME2
• PSME4
• PSMG2