Seroatlas · Human Serome Atlas

PSMG4

Proteasome assembly chaperone 4

Also known as: C6orf86, PAC4, PSMG4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JS54
Gene: PSMG4
Ensembl: ENSG00000180822
Chromosome: 6
Canonical length: 123 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to be involved in proteasome assembly. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

123 residues, UniProt reviewed canonical sequence.

>Q5JS54|PSMG4
     1  MEGLVVAAGG DVSLHNFSAR LWEQLVHFHV MRLTDSLFLW VGATPHLRNL AVAMCSRYDS
    61  IPVSTSLLGD TSDTTSTGLA QRLARKTNKQ VFVSYNLQNT DSNFALLVEN RIKEEMEAFP
   121  EKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 37 nTPM
pancreas: 34 nTPM
basal ganglia: 29 nTPM
liver: 27 nTPM
colon: 24 nTPM
pituitary gland: 23 nTPM

Single-cell type

oocytes: 530 nCPM
gastric progenitor cells: 119 nCPM
epididymal principal cells: 116 nCPM
differentiating spermatogonia: 103 nCPM
epicardial cells: 93 nCPM
myosatellite cells: 92 nCPM

Immune cell

naive B-cell: 52 nTPM
memory B-cell: 51 nTPM
memory CD4 T-cell: 42 nTPM
naive CD4 T-cell: 41 nTPM
T-reg: 40 nTPM
intermediate monocyte: 37 nTPM

Brain region

white matter: 63 nTPM
cerebellum: 56 nTPM
pons: 54 nTPM
medulla oblongata: 53 nTPM
thalamus: 49 nTPM
hypothalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: -1.3
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteasome assembly

Molecular functions

protein-containing complex binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Proteasome assembly chaperone 4
Proteasome assembly chaperone 4

KeywordsUniProt

Chaperone

InteractionsUniProt · HPA

Protein binding partners of PSMG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMG4 as an antibody target. Whether an autoantibody or antibody against PSMG4 could matter depends on whether native PSMG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMG4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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