PSMG3
Proteasome assembly chaperone 3
Also known as: C7orf48, MGC10911, PAC3, PSMG3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BT73
- Gene
- PSMG3
- Ensembl
- ENSG00000157778
- Chromosome
- 7
- Canonical length
- 122 aa
- Protein class
- Predicted intracellular proteins
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
122 residues, UniProt reviewed canonical sequence.
>Q9BT73|PSMG3
1 MEDTPLVISK QKTEVVCGVP TQVVCTAFSS HILVVVTQFG KMGTLVSLEP SSVASDVSKP
61 VLTTKVLLGQ DEPLIHVFAK NLVAFVSQEA GNRAVLLAVA VKDKSMEGLK ALREVIRVCQ
121 VWLocalizationUniProt · AlphaFold · HPA
Whether an antibody against PSMG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 56 nTPM
Expression across tissuesHPA
Tissue
- skin: 56 nTPM
- cerebral cortex: 52 nTPM
- esophagus: 52 nTPM
- bone marrow: 43 nTPM
- kidney: 41 nTPM
- amygdala: 39 nTPM
Single-cell type
- esophageal basal cells: 139 nCPM
- gastric progenitor cells: 117 nCPM
- esophageal suprabasal cells: 108 nCPM
- extravillous trophoblasts: 107 nCPM
- esophageal apical cells: 88 nCPM
- fallopian tube ciliated cells: 80 nCPM
Immune cell
- plasmacytoid DC: 71 nTPM
- basophil: 55 nTPM
- non-classical monocyte: 55 nTPM
- eosinophil: 51 nTPM
- intermediate monocyte: 50 nTPM
- MAIT T-cell: 48 nTPM
Brain region
- cerebral cortex: 30 nTPM
- thalamus: 28 nTPM
- hippocampal formation: 28 nTPM
- midbrain: 27 nTPM
- white matter: 27 nTPM
- pons: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.54
- gnomAD pLI
- 0.2
- gnomAD missense Z
- 0.52
- DepMap mean gene effect
- -1.11
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Proteasome assembly chaperone 3
- Proteasome Assembly Chaperone
- Proteasome assembly chaperone 3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of PSMG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads PSMG3 as an antibody target. Whether an autoantibody or antibody against PSMG3 could matter depends on whether native PSMG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
PSMG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label PSMG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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