Seroatlas · Human Serome Atlas

PSMB10

Proteasome subunit beta type-10

Also known as: beta2i, LMP10, MECL1, MGC1665, PSB10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P40306
Gene
PSMB10
Ensembl
ENSG00000205220
Chromosome
16
Canonical length
273 aa
Protein class
Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>P40306|PSMB10
     1  MLKPALEPRG GFSFENCQRN ASLERVLPGL KVPHARKTGT TIAGLVFQDG VILGADTRAT
    61  NDSVVADKSC EKIHFIAPKI YCCGAGVAAD AEMTTRMVAS KMELHALSTG REPRVATVTR
   121  ILRQTLFRYQ GHVGASLIVG GVDLTGPQLY GVHPHGSYSR LPFTALGSGQ DAALAVLEDR
   181  FQPNMTLEAA QGLLVEAVTA GILGDLGSGG NVDACVITKT GAKLLRTLSS PTEPVKRSGR
   241  YHFVPGTTAV LTQTVKPLTL ELVEETVQAM EVE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PSMB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 136 nTPM
  • lymph node: 115 nTPM
  • duodenum: 104 nTPM
  • small intestine: 95 nTPM
  • appendix: 77 nTPM
  • colon: 71 nTPM

Single-cell type

  • endometrial secretory cells: 11 nCPM
  • monocyte progenitors: 5.9 nCPM
  • foveolar cells: 5 nCPM
  • monocytes: 4.4 nCPM
  • nk-cells: 4.3 nCPM
  • kupffer cells: 4.1 nCPM

Immune cell

  • total PBMC: 1,156 nTPM
  • neutrophil: 790 nTPM
  • intermediate monocyte: 788 nTPM
  • classical monocyte: 716 nTPM
  • non-classical monocyte: 610 nTPM
  • plasmacytoid DC: 606 nTPM

Brain region

  • medulla oblongata: 22 nTPM
  • white matter: 21 nTPM
  • spinal cord: 15 nTPM
  • pons: 13 nTPM
  • thalamus: 12 nTPM
  • hypothalamus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PSMB10.

Disease | AllUniProt

Conditions PSMB10 is implicated in, by any mechanism.

  • Proteasome-associated autoinflammatory syndrome 5 (PRAAS5) MIM:619175
  • Immunodeficiency 121 with autoinflammation (IMD121) MIM:620807

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Proteasome-associated autoinflammatory syndrome 5
  • Immunodeficiency 121 with autoinflammation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.69
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PSMB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PSMB10 as an antibody target. Whether an autoantibody or antibody against PSMB10 could matter depends on whether native PSMB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PSMB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PSMB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PSMB10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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