DEK

Protein identityUniProt · HPA

UniProt accession

P35659

Gene

DEK

Ensembl

ENSG00000124795

Chromosome

6

Canonical length

375 aa

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>P35659|DEK
     1  MSASAPAAEG EGTPTQPASE KEPEMPGPRE ESEEEEDEDD EEEEEEEKEK SLIVEGKREK
    61  KKVERLTMQV SSLQREPFTI AQGKGQKLCE IERIHFFLSK KKTDELRNLH KLLYNRPGTV
   121  SSLKKNVGQF SGFPFEKGSV QYKKKEEMLK KFRNAMLKSI CEVLDLERSG VNSELVKRIL
   181  NFLMHPKPSG KPLPKSKKTC SKGSKKERNS SGMARKAKRT KCPEILSDES SSDEDEKKNK
   241  EESSDDEDKE SEEEPPKKTA KREKPKQKAT SKSKKSVKSA NVKKADSSTT KKNQNSSKKE
   301  SESEDSSDDE PLIKKLKKPP TDEELKETIK KLLASANLEE VTMKQICKKV YENYPTYDLT
   361  ERKDFIKTTV KELIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DEK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.54

Highest tissue expression

150 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DEK.

Disease | AutoantibodyPubMed

Conditions in which antibodies against DEK are reported. Each links to that disease's full target list.

• Arthritis, Juvenile 4
• Lupus Erythematosus, Systemic 3

ReferencesPubMed · IEDB

Publications for DEK from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.57

gnomAD pLI

0.13

gnomAD missense Z

0.4

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin remodeling
• positive regulation of transcription by RNA polymerase I
• positive regulation of transcription by RNA polymerase II
• positive regulation of transcription by RNA polymerase III
• regulation of double-strand break repair
• regulation of double-strand break repair via nonhomologous end joining
• regulation of transcription by RNA polymerase II
• signal transduction
• transcription by RNA polymerase II
• viral genome replication

Molecular functions

• DNA binding
• histone binding
• RNA binding

Cellular components

• B-WICH complex
• contractile muscle fiber
• nucleolus
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• SAP domain
• DEK, C-terminal
• SAP domain
• DEK C terminal domain
• Protein DEK

KeywordsUniProt

• Acetylation
• ADP-ribosylation
• Chromatin regulator
• Chromosomal rearrangement
• DNA-binding
• Nucleus
• Phosphoprotein
• Proto-oncogene

InteractionsUniProt · HPA

Protein binding partners of DEK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• H2B
• H3
• H4
• HDAC2
• BAZ1B
• CSNK2A1
• CSNK2A2
• DAXX