Seroatlas · Human Serome Atlas

CEP170

Centrosomal protein of 170 kDa

Also known as: CE170_HUMAN, FAM68A, KAB, KIAA0470

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SW79
Gene: CEP170
Ensembl: ENSG00000143702
Chromosome: 1
Canonical length: 1584 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome,Basal body,Cytosol

OverviewNCBI Gene

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1584 residues, UniProt reviewed canonical sequence.

>Q5SW79|CEP170
     1  MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA STDEHLVKDL
    61  GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ GEMRVPEEAL KHEKFTIQLQ
   121  LSQKSSESEL SKSASAKSID SKVADAATEV QHKTTEALKS EEKAMDISAM PRGTPLYGQP
   181  SWWGDDEVDE KRAFKTNGKP EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY
   241  FEIPTKEFQQ PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
   301  FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT EEDSKSIKSD
   361  VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL RRHHSEHKKL QKVQATEKHQ
   421  DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK
   481  NQATSATSEK DNDDDQSDKG TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK
   541  HKDLIKDWAL SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
   601  ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN EEKSLESHRA
   661  KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK MNRAVNGETL KTGGDNKTLL
   721  HLGSSAPGKE KSETDKETSL VKQTLAKLQQ QEQREEAQWT PTKLSSKNVS GQTDKCREET
   781  FKQESQPPEK NSGHSTSKGD RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT
   841  IEKPSPNIPI ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
   901  MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER KSTQKRKSFT
   961  SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG SRADGRKFVQ SSGRIRQPSV
  1021  DLTDDDQTSS VPHSAISDIM SSDQETYSCK PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP
  1081  VVSGSSSKST TLPRPRPTRT SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG
  1141  RRNISRIDLL AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
  1201  IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN SPKHTRLRTS
  1261  PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE EIARISQDLA LIAREINDVA
  1321  GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT REELVDRVFD ESLNFRKIPP LVHSKTPEGN
  1381  NGRSGDPRPQ AAEPPDHLTI TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR
  1441  ILFKDKDRNW DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
  1501  EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS AAAEFENAES
  1561  EADFSIHFNR FNPDGEEEDV TVQE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP170 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

testis: 85 nTPM
bone marrow: 50 nTPM
spinal cord: 23 nTPM
cerebellum: 22 nTPM
cerebral cortex: 16 nTPM
thyroid gland: 12 nTPM

Single-cell type

late spermatids: 1,376 nCPM
microglia: 465 nCPM
oligodendrocytes: 315 nCPM
early spermatids: 211 nCPM
oligodendrocyte progenitor cells: 158 nCPM
brain excitatory neurons: 154 nCPM

Immune cell

neutrophil: 13 nTPM
non-classical monocyte: 12 nTPM
intermediate monocyte: 11 nTPM
naive B-cell: 9.5 nTPM
myeloid DC: 9.2 nTPM
classical monocyte: 8.7 nTPM

Brain region

white matter: 196 nTPM
medulla oblongata: 133 nTPM
pons: 126 nTPM
cerebellum: 123 nTPM
spinal cord: 122 nTPM
thalamus: 118 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP170 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP170 as an antibody target. Whether an autoantibody or antibody against CEP170 could matter depends on whether native CEP170 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP170 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP170 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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