Seroatlas · Human Serome Atlas

ESF1

ESF1 homolog

Also known as: bA526K24.1, C20orf6, ESF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H501
Gene: ESF1
Ensembl: ENSG00000089048
Chromosome: 20
Canonical length: 851 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

851 residues, UniProt reviewed canonical sequence.

>Q9H501|ESF1
     1  MSSKQEIMSD QRFRRVAKDP RFWEMPEKDR KVKIDKRFRA MFHDKKFKLN YAVDKRGRPI
    61  SHSTTEDLKR FYDLSDSDSN LSGEDSKALS QKKIKKKKTQ TKKEIDSKNL VEKKKETKKA
   121  NHKGSENKTD LDNSIGIKKM KTSCKFKIDS NISPKKDSKE FTQKNKKEKK NIVQHTTDSS
   181  LEEKQRTLDS GTSEIVKSPR IECSKTRREM QSVVQLIMTR DSDGYENSTD GEMCDKDALE
   241  EDSESVSEIG SDEESENEIT SVGRASGDDD GSEDDEEEDE DEEEDEDEDS EDDDKSDSGP
   301  DLARGKGNIE TSSEDEDDTA DLFPEESGFE HAWRELDKDA PRADEITRRL AVCNMDWDRL
   361  KAKDLLALFN SFKPKGGVIF SVKIYPSEFG KERMKEEQVQ GPVELLSIPE DAPEKDWTSR
   421  EKLRDYQFKR LKYYYAVVDC DSPETASKIY EDCDGLEFES SCSFIDLRFI PDDITFDDEP
   481  KDVASEVNLT AYKPKYFTSA AMGTSTVEIT WDETDHERIT MLNRKFKKEE LLDMDFQAYL
   541  ASSSEDEEEI EEELQGDDGV NVEEDGKTKK SQKDDEEQIA KYRQLLQVIQ EKEKKGKEND
   601  MEMEIKWVPG LKESAEEMVK NKLEGKDKLT PWEQFLEKKK EKKRLKRKQK ALAEEASEEE
   661  LPSDVDLNDP YFAEEVKQIG INKKSVKSAK DGTSPEEEIE IERQKAEMAL LMMDEDEDSK
   721  KHFNYNKIVE HQNLSKKKKK QLMKKKELIE DDFEVNVNDA RFQAMYTSHL FNLDPSDPNF
   781  KKTKAMEKIL EEKARQRERK EQELTQAIKK KESEIEKESQ RKSIDPALSM LIKSIKTKTE
   841  QFQARKKQKV K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ESF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 16 nTPM
testis: 13 nTPM
liver: 13 nTPM
skeletal muscle: 12 nTPM
midbrain: 12 nTPM
urinary bladder: 12 nTPM

Single-cell type

early primary spermatocytes: 287 nCPM
oocytes: 263 nCPM
differentiating spermatogonia: 233 nCPM
sertoli cells: 185 nCPM
late primary spermatocytes: 145 nCPM
ovarian stromal cells: 138 nCPM

Immune cell

plasmacytoid DC: 19 nTPM
memory B-cell: 18 nTPM
naive B-cell: 18 nTPM
NK-cell: 15 nTPM
naive CD4 T-cell: 15 nTPM
non-classical monocyte: 14 nTPM

Brain region

medulla oblongata: 24 nTPM
white matter: 22 nTPM
spinal cord: 22 nTPM
hypothalamus: 21 nTPM
thalamus: 21 nTPM
midbrain: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.02
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.79
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

rRNA processing

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

NUC153
Nucleotide-binding alpha-beta plait domain superfamily
NUC153 domain
Pre-rRNA-processing protein Esf1
ESF1, RRM domain
ESF1 RRM domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ESF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ESF1 as an antibody target. Whether an autoantibody or antibody against ESF1 could matter depends on whether native ESF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ESF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ESF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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