Seroatlas · Human Serome Atlas

AIP

AH receptor-interacting protein

Also known as: AIP_HUMAN, ARA9, FKBP16, FKBP37, XAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00170
Gene
AIP
Ensembl
ENSG00000110711
Chromosome
11
Canonical length
330 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

330 residues, UniProt reviewed canonical sequence.

>O00170|AIP
     1  MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL DDSRARGKPM
    61  ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL VAKSLRNIAV GKDPLEGQRH
   121  CCGVAQMREH SSLGHADLDA LQQNPQPLIF HMEMLKVESP GTYQQDPWAM TDEEKAKAVP
   181  LIHQEGNRLY REGHVKEAAA KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC
   241  KLVVEEYYEV LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
   301  VVSRELRALE ARIRQKDEED KARFRGIFSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 95 nTPM
  • lymph node: 77 nTPM
  • spleen: 74 nTPM
  • choroid plexus: 73 nTPM
  • kidney: 70 nTPM
  • ovary: 70 nTPM

Single-cell type

  • oocytes: 115 nCPM
  • decidual stromal cells: 95 nCPM
  • extravillous trophoblasts: 84 nCPM
  • enterocytes: 80 nCPM
  • hofbauer cells: 75 nCPM
  • ovarian stromal cells: 70 nCPM

Immune cell

  • T-reg: 352 nTPM
  • memory B-cell: 241 nTPM
  • memory CD4 T-cell: 228 nTPM
  • memory CD8 T-cell: 227 nTPM
  • naive B-cell: 222 nTPM
  • MAIT T-cell: 212 nTPM

Brain region

  • white matter: 60 nTPM
  • basal ganglia: 56 nTPM
  • medulla oblongata: 54 nTPM
  • cerebellum: 52 nTPM
  • pons: 51 nTPM
  • hypothalamus: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AIP.

Disease | AllUniProt

Conditions AIP is implicated in, by any mechanism.

  • Pituitary adenoma 1, multiple types (PITA1) MIM:102200

Disease | GeneticClinVar

71 pathogenic / likely-pathogenic of 1,222 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0.36
gnomAD missense Z
0.93
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AIP as an antibody target. Whether an autoantibody or antibody against AIP could matter depends on whether native AIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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