Seroatlas · Human Serome Atlas

FAM133A

Protein FAM133A

Also known as: CT115, F133A_HUMAN, FLJ37659, RP1-32F7.2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9E0
Gene: FAM133A
Ensembl: ENSG00000179083
Chromosome: X
Canonical length: 248 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

No narrative summary is available for FAM133A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q8N9E0|FAM133A
     1  MGKRDNRVAY MNPIAMARWR GPTQSVGPTI QDYLNRPRPT WEEVKKQLEN KKTGSKALAE
    61  FEEKMNENWK KELEKSREKL LSGNESSSKK RERKKKRKKK SCRSSSSSSS SDSSSSSSDS
   121  EDEEKKQGKR RKKKKNRSYK SSQSSTHESE SESKESVKKK KKSKDETEKE KDVRSLSKKR
   181  KKSYPDDKPL SSESSSESDY EEDVQAKKKR RCEEREQAKE KVKKKKKKQH KKHSKKKKKK
   241  SGSSHKSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM133A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 7.3 nTPM

Expression across tissuesHPA

Tissue

testis: 7.3 nTPM
cerebral cortex: 2.9 nTPM
basal ganglia: 1.5 nTPM
hypothalamus: 1.4 nTPM
retina: 1.3 nTPM
adrenal gland: 1.2 nTPM

Single-cell type

sertoli cells: 386 nCPM
differentiating spermatogonia: 44 nCPM
late spermatids: 42 nCPM
undifferentiated spermatogonia: 38 nCPM
somatotrophs: 36 nCPM
adrenal medulla cells: 32 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 6.9 nTPM
pons: 6.1 nTPM
midbrain: 5.6 nTPM
basal ganglia: 4.6 nTPM
cerebral cortex: 4.1 nTPM
thalamus: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.95
gnomAD pLI: 0.4
gnomAD missense Z: 0.07
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Protein FAM133

InteractionsUniProt · HPA

Protein binding partners of FAM133A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM133A as an antibody target. Whether an autoantibody or antibody against FAM133A could matter depends on whether native FAM133A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM133A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM133A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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