Seroatlas · Human Serome Atlas

CCAR2

Cell cycle and apoptosis regulator protein 2

Also known as: CCAR2_HUMAN, DBC-1, DBC1, KIAA1967, NET35

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N163
Gene: CCAR2
Ensembl: ENSG00000158941
Chromosome: 8
Canonical length: 923 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; regulation of primary metabolic process; and regulation of signal transduction. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

923 residues, UniProt reviewed canonical sequence.

>Q8N163|CCAR2
     1  MSQFKRQRIN PLPGGRNFSG TASTSLLGPP PGLLTPPVAT ELSQNARHLQ GGEKQRVFTG
    61  IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY NPGQAVPWNA VKVQTLSNQP
   121  LLKSPAPPLL HVAALGQKQG ILGAQPQLIF QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR
   181  FPARGPHGRL DQGRSDDYDS KKRKQRAGGE PWGAKKPRHD LPPYRVHLTP YTVDSPICDF
   241  LELQRRYRSL LVPSDFLSVH LSWLSAFPLS QPFSLHHPSR IQVSSEKEAA PDAGAEPITA
   301  DSDPAYSSKV LLLSSPGLEE LYRCCMLFVD DMAEPRETPE HPLKQIKFLL GRKEEEAVLV
   361  GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSGCT KWWRFAEFQY LQPGPPRRLQ
   421  TVVVYLPDVW TIMPTLEEWE ALCQQKAAEA APPTQEAQGE TEPTEQAPDA LEQAADTSRR
   481  NAETPEATTQ QETDTDLPEA PPPPLEPAVI ARPGCVNLSL HGIVEDRRPK ERISFEVMVL
   541  AELFLEMLQR DFGYRVYKML LSLPEKVVSP PEPEKEEAAK EEATKEEEAI KEEVVKEPKD
   601  EAQNEGPATE SEAPLKEDGL LPKPLSSGGE EEEKPRGEAS EDLCEMALDP ELLLLRDDGE
   661  EEFAGAKLED SEVRSVASNQ SEMEFSSLQD MPKELDPSAV LPLDCLLAFV FFDANWCGYL
   721  HRRDLERILL TLGIRLSAEQ AKQLVSRVVT QNICQYRSLQ YSRQEGLDGG LPEEVLFGNL
   781  DLLPPPGKST KPGAAPTEHK ALVSHNGSLI NVGSLLQRAE QQDSGRLYLE NKIHTLELKL
   841  EESHNRFSAT EVTNKTLAAE MQELRVRLAE AEETARTAER QKSQLQRLLQ ELRRRLTPLQ
   901  LEIQRVVEKA DSWVEKEEPA PSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCAR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 123 nTPM
testis: 69 nTPM
spleen: 66 nTPM
cerebellum: 64 nTPM
skeletal muscle: 63 nTPM
skin: 63 nTPM

Single-cell type

epicardial cells: 77 nCPM
podocytes: 48 nCPM
early primary spermatocytes: 37 nCPM
cytotrophoblasts: 36 nCPM
cardiomyocytes: 34 nCPM
endometrial luminal cells: 32 nCPM

Immune cell

gdT-cell: 22 nTPM
non-classical monocyte: 22 nTPM
T-reg: 22 nTPM
basophil: 21 nTPM
MAIT T-cell: 18 nTPM
naive CD8 T-cell: 18 nTPM

Brain region

choroid plexus: 136 nTPM
cerebral cortex: 134 nTPM
white matter: 125 nTPM
hippocampal formation: 122 nTPM
cerebellum: 119 nTPM
midbrain: 119 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.94
gnomAD missense Z: 0.73
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCAR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCAR2 as an antibody target. Whether an autoantibody or antibody against CCAR2 could matter depends on whether native CCAR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCAR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCAR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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