CDC37
Hsp90 co-chaperone Cdc37
Also known as: CDC37_HUMAN, P50CDC37
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q16543
- Gene
- CDC37
- Ensembl
- ENSG00000105401
- Chromosome
- 19
- Canonical length
- 378 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins, Transporters
- Subcellular location
- Cytosol
OverviewNCBI Gene
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
378 residues, UniProt reviewed canonical sequence.
>Q16543|CDC37
1 MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK
61 VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS
121 KDGFSKSMVN TKPEKTEEDS EEVREQKHKT FVEKYEKQIK HFGMLRRWDD SQKYLSDNVH
181 LVCEETANYL VIWCIDLEVE EKCALMEQVA HQTIVMQFIL ELAKSLKVDP RACFRQFFTK
241 IKTADRQYME GFNDELEAFK ERVRGRAKLR IEKAMKEYEE EERKKRLGPG GLDPVEVYES
301 LPEELQKCFD VKDVQMLQDA ISKMDPTDAK YHMQRCIDSG LWVPNSKASE AKEGEEAGPG
361 DPLLEAVPKT GDEKDVSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDC37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 293 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 293 nTPM
- tongue: 208 nTPM
- heart muscle: 176 nTPM
- adipose tissue: 142 nTPM
- spleen: 132 nTPM
- breast: 126 nTPM
Single-cell type
- extravillous trophoblasts: 623 nCPM
- late spermatids: 404 nCPM
- esophageal apical cells: 313 nCPM
- syncytiotrophoblasts: 273 nCPM
- esophageal suprabasal cells: 268 nCPM
- cdc: 251 nCPM
Immune cell
- total PBMC: 146 nTPM
- gdT-cell: 115 nTPM
- non-classical monocyte: 113 nTPM
- classical monocyte: 111 nTPM
- intermediate monocyte: 108 nTPM
- T-reg: 107 nTPM
Brain region
- cerebral cortex: 120 nTPM
- pons: 99 nTPM
- midbrain: 94 nTPM
- medulla oblongata: 94 nTPM
- white matter: 94 nTPM
- hypothalamus: 92 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.37
- gnomAD pLI
- 0.91
- gnomAD missense Z
- 1.68
- DepMap mean gene effect
- -1.15
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of type 2 mitophagy
- post-transcriptional regulation of gene expression
- protein folding
- protein stabilization
- protein targeting
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of type I interferon-mediated signaling pathway
- regulation of type II interferon-mediated signaling pathway
Molecular functions
- heat shock protein binding
- Hsp90 protein binding
- kinase binding
- protein kinase binding
- protein kinase regulator activity
- protein-folding chaperone binding
- scaffold protein binding
- unfolded protein binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cdc37
- Cdc37, Hsp90 binding
- Cdc37, Hsp90-binding domain superfamily
- Cdc37 Hsp90 binding domain
- Cdc37, N-terminal domain
- Cdc37, C-terminal
- Cdc37 N terminal kinase binding
- Cdc37 C terminal domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDC37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDC37 as an antibody target. Whether an autoantibody or antibody against CDC37 could matter depends on whether native CDC37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDC37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDC37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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