Seroatlas · Human Serome Atlas

GATAD2A

Transcriptional repressor p66-alpha

Also known as: P66A_HUMAN, p66alpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YP4
Gene: GATAD2A
Ensembl: ENSG00000167491
Chromosome: 19
Canonical length: 633 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homooligomer

OverviewNCBI Gene

Enables protein-macromolecule adaptor activity. Involved in chromatin remodeling and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of NuRD complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>Q86YP4|GATAD2A
     1  MTEEACRTRS QKRALERDPT EDDVESKKIK MERGLLASDL NTDGDMRVTP EPGAGPTQGL
    61  LRATEATAMA MGRGEGLVGD GPVDMRTSHS DMKSERRPPS PDVIVLSDNE QPSSPRVNGL
   121  TTVALKETST EALMKSSPEE RERMIKQLKE ELRLEEAKLV LLKKLRQSQI QKEATAQKPT
   181  GSVGSTVTTP PPLVRGTQNI PAGKPSLQTS SARMPGSVIP PPLVRGGQQA SSKLGPQASS
   241  QVVMPPLVRG AQQIHSIRQH SSTGPPPLLL APRASVPSVQ IQGQRIIQQG LIRVANVPNT
   301  SLLVNIPQPT PASLKGTTAT SAQANSTPTS VASVVTSAES PASRQAAAKL ALRKQLEKTL
   361  LEIPPPKPPA PEMNFLPSAA NNEFIYLVGL EEVVQNLLET QGRMSAATVL SREPYMCAQC
   421  KTDFTCRWRE EKSGAIMCEN CMTTNQKKAL KVEHTSRLKA AFVKALQQEQ EIEQRLLQQG
   481  TAPAQAKAEP TAAPHPVLKQ VIKPRRKLAF RSGEARDWSN GAVLQASSQL SRGSATTPRG
   541  VLHTFSPSPK LQNSASATAL VSRTGRHSER TVSAGKGSAT SNWKKTPLST GGTLAFVSPS
   601  LAVHKSSSAV DRQREYLLDM IPPRSIPQSA TWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GATAD2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 31 nTPM
testis: 31 nTPM
small intestine: 23 nTPM
appendix: 22 nTPM
duodenum: 21 nTPM
spleen: 21 nTPM

Single-cell type

neutrophils: 616 nCPM
neutrophil progenitors: 255 nCPM
endometrial glandular cells: 236 nCPM
sertoli cells: 222 nCPM
nk-cells: 199 nCPM
suprabasal keratinocytes: 196 nCPM

Immune cell

neutrophil: 7.7 nTPM
basophil: 4.7 nTPM
non-classical monocyte: 3.3 nTPM
eosinophil: 3.2 nTPM
gdT-cell: 3.2 nTPM
plasmacytoid DC: 3 nTPM

Brain region

medulla oblongata: 38 nTPM
choroid plexus: 38 nTPM
hippocampal formation: 34 nTPM
thalamus: 34 nTPM
pons: 32 nTPM
midbrain: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GATAD2A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 135 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

GATAD2A-associated neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GATAD2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GATAD2A as an antibody target. Whether an autoantibody or antibody against GATAD2A could matter depends on whether native GATAD2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GATAD2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GATAD2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...