Seroatlas · Human Serome Atlas

EIF3D

Eukaryotic translation initiation factor 3 subunit D

Also known as: eIF3-p66, eIF3-zeta, EIF3D_HUMAN, EIF3S7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15371
Gene: EIF3D
Ensembl: ENSG00000100353
Chromosome: 22
Canonical length: 548 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

548 residues, UniProt reviewed canonical sequence.

>O15371|EIF3D
     1  MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS
    61  SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ
   121  ILPKSAKQKE RERIRLQKKF QKQFGVRQKW DQKSQKPRDS SVEVRSDWEV KEEMDFPQLM
   181  KMRYLEVSEP QDIECCGALE YYDKAFDRIT TRSEKPLRSI KRIFHTVTTT DDPVIRKLAK
   241  TQGNVFATDA ILATLMSCTR SVYSWDIVVQ RVGSKLFFDK RDNSDFDLLT VSETANEPPQ
   301  DEGNSFNSPR NLAMEATYIN HNFSQQCLRM GKERYNFPNP NPFVEDDMDK NEIASVAYRY
   361  RRWKLGDDID LIVRCEHDGV MTGANGEVSF INIKTLNEWD SRHCNGVDWR QKLDSQRGAV
   421  IATELKNNSY KLARWTCCAL LAGSEYLKLG YVSRYHVKDS SRHVILGTQQ FKPNEFASQI
   481  NLSVENAWGI LRCVIDICMK LEEGKYLILK DPNKQVIRVY SLPDGTFSSD EDEEEEEEEE
   541  EEEEEEET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 240 nTPM

Expression across tissuesHPA

Tissue

pancreas: 240 nTPM
tonsil: 199 nTPM
ovary: 181 nTPM
breast: 173 nTPM
bone marrow: 167 nTPM
lymph node: 163 nTPM

Single-cell type

esophageal apical cells: 458 nCPM
esophageal basal cells: 382 nCPM
decidual stromal cells: 376 nCPM
esophageal suprabasal cells: 371 nCPM
pancreatic acinar cells: 352 nCPM
breast secretory cells: 332 nCPM

Immune cell

total PBMC: 826 nTPM
T-reg: 610 nTPM
naive CD4 T-cell: 560 nTPM
myeloid DC: 529 nTPM
MAIT T-cell: 521 nTPM
memory B-cell: 520 nTPM

Brain region

choroid plexus: 64 nTPM
white matter: 50 nTPM
medulla oblongata: 49 nTPM
thalamus: 49 nTPM
spinal cord: 44 nTPM
cerebral cortex: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.49
DepMap mean gene effect: -1.71
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Eukaryotic translation initiation factor 3 subunit D
Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF3D as an antibody target. Whether an autoantibody or antibody against EIF3D could matter depends on whether native EIF3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF3D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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