ARK2N
Protein ARK2N
Also known as: ARK2N_HUMAN, ARKL1, C18orf25, MGC12909, RNF111L1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96B23
- Gene
- ARK2N
- Ensembl
- ENSG00000152242
- Chromosome
- 18
- Canonical length
- 404 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables transcription corepressor activity. Involved in negative regulation of viral life cycle. Is active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
404 residues, UniProt reviewed canonical sequence.
>Q96B23|ARK2N
1 MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST VISSMPCLLM
61 ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS GHLADSDTLS SAEENEPSQA
121 ETAVEGDPSG VSGATVGRKS RRSRSESETS TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK
181 ERIRLLRQKR EAAARKKYNL LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG
241 PPVVAHYDMS DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
301 HLDPGFLASD KTSAGNAPLN EEINIASSDS EVEIVGVQEH ARCVHPRGGV IQSVSSWKHG
361 SGTQYVSTRQ TQSWTAVTPQ QTWASPAEVV DLTLDEDSRR KYLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ARK2N can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 35 nTPM
- bone marrow: 32 nTPM
- retina: 26 nTPM
- skeletal muscle: 22 nTPM
- parathyroid gland: 18 nTPM
- vagina: 15 nTPM
Single-cell type
- esophageal apical cells: 777 nCPM
- neutrophil progenitors: 296 nCPM
- endometrial glandular cells: 250 nCPM
- neutrophils: 235 nCPM
- myonuclei: 191 nCPM
- endometrial ciliated cells: 170 nCPM
Immune cell
- neutrophil: 23 nTPM
- eosinophil: 19 nTPM
- non-classical monocyte: 14 nTPM
- plasmacytoid DC: 13 nTPM
- memory CD4 T-cell: 12 nTPM
- MAIT T-cell: 11 nTPM
Brain region
- choroid plexus: 44 nTPM
- midbrain: 33 nTPM
- cerebellum: 31 nTPM
- medulla oblongata: 30 nTPM
- thalamus: 27 nTPM
- cerebral cortex: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.39
- gnomAD pLI
- 0.89
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ARK2N in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ARK2N as an antibody target. Whether an autoantibody or antibody against ARK2N could matter depends on whether native ARK2N is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ARK2N is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ARK2N as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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